{"id":"W4403019159","doi":"10.1101/2024.09.29.615684","title":"Treatment with carnosic acid attenuates the secretion of pro-inflammatory mast cell mediators following IL-33 activation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"","keywords":"Carnosic acid; Secretion; Mast cell; Chemistry; Interleukin 33; Inflammation; Cell biology; Interleukin; Pharmacology; Immunology; Medicine; Biochemistry; Cytokine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004254626,0.0007615762,0.0007577108,0.0002488523,0.0003079693,0.00008417952,0.0004731838,0.0008578117,0.00002632746],"category_scores_gemma":[0.00006700149,0.0005399983,0.0003133898,0.0004419923,0.0002770213,0.0001309685,0.0003409366,0.0009569006,0.0002049807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004459134,"about_ca_system_score_gemma":0.001189098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009896092,"about_ca_topic_score_gemma":0.00001157872,"domain_scores_codex":[0.997264,0.0003145418,0.000641655,0.0009691653,0.0001870426,0.0006236216],"domain_scores_gemma":[0.9977717,0.0001270452,0.0006026184,0.001112576,0.0003151777,0.00007083746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001292034,0.0001517718,0.004852766,0.0006103389,0.000831685,0.00003215101,0.0003166172,0.00001660592,0.9926988,0.00021539,0.0001319426,0.00001273572],"study_design_scores_gemma":[0.001061642,0.000352891,0.006757471,0.0006083311,0.0006171429,1.060988e-7,0.0000862584,0.00001988327,0.9773408,0.000004375282,0.01255334,0.000597812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908905,0.002233485,0.000150339,0.0001391501,0.002270287,0.001364716,0.002540171,0.0003504917,0.00006086634],"genre_scores_gemma":[0.9984472,0.000331164,0.0001861926,0.00003772208,0.0002742879,0.000513687,0.00001408635,0.0001472849,0.0000483689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01535804,"threshold_uncertainty_score":0.9997051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009033140924242164,"score_gpt":0.1925128245012122,"score_spread":0.18347968357697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}