{"id":"W4403041439","doi":"10.3390/diseases12100234","title":"CDX2-Suppressed Colorectal Cancers Possess Potentially Targetable Alterations in Receptor Tyrosine Kinases and Other Colorectal-Cancer-Associated Pathways","year":2024,"lang":"en","type":"article","venue":"Diseases","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"KRAS; Colorectal cancer; CDX2; Medicine; Microsatellite instability; Cancer research; Receptor tyrosine kinase; Oncology; Internal medicine; Cancer; Wnt signaling pathway; Biology; Gene; Receptor; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005633,0.0002129016,0.0001804947,0.0004325936,0.0001777563,0.0003778837,0.0001214333,0.0001569262,0.001588729],"category_scores_gemma":[0.0002586438,0.0000605292,0.0001726282,0.000352986,0.0001971538,0.0001355011,0.0002771002,0.0001482266,0.000180673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001690027,"about_ca_system_score_gemma":0.0001219183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002379091,"about_ca_topic_score_gemma":0.0003254818,"domain_scores_codex":[0.9998603,0.00001446041,0.00001749576,0.00003787491,0.00004049813,0.00002932054],"domain_scores_gemma":[0.9997054,0.00003772882,0.0001397011,0.00003641692,0.00003279875,0.00004804265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001403608,0.0001012436,0.4480166,0.0001995136,0.0001263095,0.001874232,0.0001724719,0.0002293113,0.5345063,0.0004721852,0.0002959336,0.01260241],"study_design_scores_gemma":[0.000063271,0.0008082784,0.8649672,0.00002240649,0.00015607,0.01422729,0.0002361192,0.0008860413,0.1119809,0.0002900054,0.006353154,0.000009109732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981444,0.0004805983,0.0003680053,0.00001966074,0.00000305825,0.000009321431,0.0002111834,0.0000125769,0.0007512275],"genre_scores_gemma":[0.9987073,0.0001316121,0.0002764149,0.00001796597,0.00000388341,0.000009767185,0.0004515964,0.000003967518,0.0003974308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001588729,"threshold_uncertainty_score":0.005314827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00900757601457452,"score_gpt":0.2600166244969847,"score_spread":0.2510090484824102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}