{"id":"W4403041439","doi":"10.3390/diseases12100234","title":"CDX2-Suppressed Colorectal Cancers Possess Potentially Targetable Alterations in Receptor Tyrosine Kinases and Other Colorectal-Cancer-Associated Pathways","year":2024,"lang":"en","type":"article","venue":"Diseases","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"KRAS; Colorectal cancer; CDX2; Medicine; Microsatellite instability; Cancer research; Receptor tyrosine kinase; Oncology; Internal medicine; Cancer; Wnt signaling pathway; Biology; Gene; Receptor; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008098803,0.0001796205,0.0001961073,0.00007303298,0.0001208115,0.00009702471,0.00008481309,0.0001465881,0.0001136437],"category_scores_gemma":[0.00007406682,0.0001589202,0.00007120144,0.0002022914,0.00009496348,0.00001378672,0.00004456562,0.00008648946,0.000008899527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009226346,"about_ca_system_score_gemma":0.0005160007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007698068,"about_ca_topic_score_gemma":0.0007700841,"domain_scores_codex":[0.9988452,0.0001040407,0.0002232055,0.000407257,0.0001182261,0.0003021005],"domain_scores_gemma":[0.9996077,0.00002968395,0.00005536031,0.00009523457,0.00007035721,0.0001415942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005530493,0.0004514278,0.07996739,0.0003769131,0.000398053,0.00005234169,0.0004129957,0.001114169,0.9028354,0.0006358762,0.01153797,0.001664463],"study_design_scores_gemma":[0.005857294,0.002643217,0.3270719,0.00300172,0.0006263736,0.00003572726,0.001224775,0.004277173,0.5733008,0.0004515214,0.07907304,0.002436451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743722,0.02195236,0.00003118634,0.0001709847,0.0005678022,0.0003834729,0.00172183,0.00005438981,0.0007457459],"genre_scores_gemma":[0.9973626,0.001080973,0.00002406478,0.000155812,0.0001725667,0.0001679996,0.0005691014,0.00003636738,0.0004305865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3295345,"threshold_uncertainty_score":0.6480576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00900757601457452,"score_gpt":0.2600166244969847,"score_spread":0.2510090484824102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}