{"id":"W4403048817","doi":"10.1093/nar/gkae849","title":"Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil","year":2024,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Queen's University Belfast; University of Manchester; Academy of Medical Sciences; Queen's University; Christie Charity","keywords":"Ribosome; Biology; Translation (biology); Messenger RNA; Protein biosynthesis; Cytotoxic T cell; Internal ribosome entry site; PI3K/AKT/mTOR pathway; Cell biology; RNA; Cytotoxicity; Cancer research; Molecular biology; Signal transduction; In vitro; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001743391,0.0001364747,0.0001831058,0.00007346959,0.0003023552,0.0001072627,0.0005596677,0.0002040062,0.0001546629],"category_scores_gemma":[0.0004503429,0.0000955458,0.0001366349,0.000460433,0.0004271994,0.00001108925,0.0001636905,0.0004187265,0.00005949304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005557759,"about_ca_system_score_gemma":0.0002750171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000211747,"about_ca_topic_score_gemma":0.00002411654,"domain_scores_codex":[0.9977751,0.0004972946,0.0003321164,0.0004244657,0.0005713339,0.000399712],"domain_scores_gemma":[0.9985003,0.0002301218,0.00004846444,0.0007225535,0.0003791515,0.0001194224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006223792,0.00007906523,0.0007100466,0.00003705288,0.00008517511,0.000001117006,0.0001005982,0.000006753727,0.981876,0.002125867,0.01263203,0.002284089],"study_design_scores_gemma":[0.0007934832,0.000524723,0.01683921,0.00006821614,0.00002464992,0.000006630018,0.0007049899,0.0006413262,0.8858267,0.001185839,0.09309438,0.0002898637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905256,0.003184256,0.0003422252,0.002970228,0.00009700512,0.0004275544,0.0004492096,0.00002132219,0.001982594],"genre_scores_gemma":[0.9974477,0.000501436,0.00004832846,0.0001148635,0.0001717669,0.0001495821,0.00006900557,0.00002715146,0.00147012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09604928,"threshold_uncertainty_score":0.3896245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05482609038394123,"score_gpt":0.3807916567322663,"score_spread":0.3259655663483251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}