{"id":"W4403053021","doi":"10.1038/s41598-024-74391-8","title":"Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Transcription factor; Cell biology; Biology; Bioinformatics; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000868694,0.0002882798,0.0002824302,0.0002599145,0.0001404095,0.0002496723,0.0001176972,0.0001771452,0.001079461],"category_scores_gemma":[0.0001227247,0.00011117,0.0002464433,0.0002514384,0.000168452,0.0001161253,0.0001560315,0.0005089444,0.0003910914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003428947,"about_ca_system_score_gemma":0.0001755701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001427439,"about_ca_topic_score_gemma":0.001336737,"domain_scores_codex":[0.999853,0.00002072519,0.00001369744,0.00003165495,0.00004540806,0.00003549425],"domain_scores_gemma":[0.9999219,0.00001104046,0.00002131805,0.00001280655,0.00001504374,0.00001789744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005312662,0.00000492755,0.0002270176,0.000009541797,0.000001240131,0.00001934245,0.000007169597,0.00001596056,0.9993099,0.00001102185,0.00001012621,0.0003306841],"study_design_scores_gemma":[0.00001132074,0.0001042838,0.02501229,0.000005218047,0.00001492905,0.0001562911,0.00006184036,0.0008136689,0.9718378,0.00004736105,0.001929333,0.000005657938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99229,0.001549884,0.003393307,0.000153229,0.00004328044,0.00003293755,0.0009440674,0.0001055243,0.001487861],"genre_scores_gemma":[0.993076,0.0005739777,0.00199049,0.00008177252,0.000008425098,0.00002569134,0.001434914,0.00002161978,0.002787125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001427439,"threshold_uncertainty_score":0.003611207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02121289870847147,"score_gpt":0.258304963729787,"score_spread":0.2370920650213155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}