{"id":"W4403054910","doi":"10.1021/acsinfecdis.4c00553","title":"High Affinity Inhibitors of the Macrophage Infectivity Potentiator Protein from <i>Trypanosoma cruzi</i>, <i>Burkholderia pseudomallei</i>, and <i>Legionella pneumophila</i>─A Comparison","year":2024,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"Defence Science and Technology Group; Defence Science and Technology Laboratory; Bundesministerium für Bildung und Forschung; Rijksuniversiteit Groningen; Friedrich-Schiller-Universität Jena","keywords":"Legionella pneumophila; Burkholderia pseudomallei; Potentiator; Infectivity; Microbiology; Trypanosoma cruzi; Melioidosis; Biology; Virology; Legionella; Macrophage; Immunology; Bacteria; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00001969552,0.0003588766,0.0005675659,0.0001844681,0.0003744022,0.0001901033,0.0002190927,0.0001819928,0.00009031048],"category_scores_gemma":[0.0004539408,0.0002672942,0.0003055052,0.0008040201,0.0005826387,0.0002744988,0.0003730099,0.0005642876,0.00006541583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001310342,"about_ca_system_score_gemma":0.0003646199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008416669,"about_ca_topic_score_gemma":0.0001189763,"domain_scores_codex":[0.9975899,0.0001846978,0.0005336934,0.0006369431,0.0006039193,0.000450819],"domain_scores_gemma":[0.998077,0.000298689,0.0001662907,0.0008430541,0.0001953412,0.0004195754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001365663,0.001201071,0.08840903,0.0004802073,0.0003514283,0.00005252221,0.0001183832,0.00001487619,0.896727,0.001855797,0.008075525,0.002577619],"study_design_scores_gemma":[0.001162281,0.0003544561,0.8711272,0.0003813887,0.0003238183,0.00007059582,0.00005592753,0.00006881291,0.1195787,0.002775709,0.003833544,0.0002675689],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910896,0.003458664,0.00007419821,0.001646369,0.0005617978,0.00140402,0.0006563569,0.0003305981,0.0007783769],"genre_scores_gemma":[0.998385,0.0002829729,0.00004323092,0.000250707,0.0004979896,0.0002070439,0.00006901834,0.00006372324,0.0002003272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7827182,"threshold_uncertainty_score":0.9999779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009486624601575492,"score_gpt":0.2588701181601417,"score_spread":0.2493834935585662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}