{"id":"W4403054910","doi":"10.1021/acsinfecdis.4c00553","title":"High Affinity Inhibitors of the Macrophage Infectivity Potentiator Protein from <i>Trypanosoma cruzi</i>, <i>Burkholderia pseudomallei</i>, and <i>Legionella pneumophila</i>─A Comparison","year":2024,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"Defence Science and Technology Group; Defence Science and Technology Laboratory; Bundesministerium für Bildung und Forschung; Rijksuniversiteit Groningen; Friedrich-Schiller-Universität Jena","keywords":"Legionella pneumophila; Burkholderia pseudomallei; Potentiator; Infectivity; Microbiology; Trypanosoma cruzi; Melioidosis; Biology; Virology; Legionella; Macrophage; Immunology; Bacteria; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307633,0.0003778675,0.0001758002,0.0001967894,0.0001179235,0.0001440351,0.0003254811,0.00024724,0.003543046],"category_scores_gemma":[0.00009825641,0.0001166332,0.0001737451,0.0001515136,0.00008575955,0.0001413822,0.00009975941,0.0003782832,0.0005427897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001809147,"about_ca_system_score_gemma":0.00013247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006394434,"about_ca_topic_score_gemma":0.001215943,"domain_scores_codex":[0.9998912,0.00001759558,0.000007220165,0.00001364154,0.00004045245,0.00002993954],"domain_scores_gemma":[0.9999388,0.00002421456,0.00001051007,0.000003516271,0.00001204937,0.00001092419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002613493,0.00008518294,0.00007378278,0.00008622668,0.00001181369,0.00003931492,0.000009409681,0.0002897749,0.9960169,0.0001207585,0.0005004641,0.002504964],"study_design_scores_gemma":[0.00003611968,0.0005814795,0.001120879,0.000004909261,0.00001240822,0.0001222722,0.0000107181,0.001744917,0.9935249,0.00003113586,0.002804873,0.000005274489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691538,0.007046942,0.006415732,0.0003926562,0.0001554373,0.0001041446,0.001337565,0.0002215227,0.01517226],"genre_scores_gemma":[0.9687172,0.005061826,0.0078588,0.0002064707,0.00003375173,0.0001393826,0.003783522,0.00002970971,0.01416939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003543046,"threshold_uncertainty_score":0.01185268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009486624601575492,"score_gpt":0.2588701181601417,"score_spread":0.2493834935585662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}