{"id":"W4403055882","doi":"10.1101/2024.10.01.24314116","title":"Plasma cell-free DNA methylomes for hepatocellular carcinoma detection and monitoring after liver resection or transplantation","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre; Toronto General Hospital; University Health Network","funders":"","keywords":"Liver transplantation; Hepatocellular carcinoma; Resection; Transplantation; Cancer research; Medicine; Chemistry; Internal medicine; Oncology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004322504,0.000313635,0.0003370227,0.0005164426,0.0001971004,0.0003196235,0.0003282233,0.000435478,0.001145334],"category_scores_gemma":[0.0008245328,0.0001533134,0.0003354254,0.0003005499,0.0001608599,0.0001609139,0.0003052689,0.0003477093,0.0002952692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002644972,"about_ca_system_score_gemma":0.0002205258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112721,"about_ca_topic_score_gemma":0.001806672,"domain_scores_codex":[0.9997467,0.00005186696,0.00001648774,0.0001026259,0.00005868072,0.00002367547],"domain_scores_gemma":[0.9995379,0.0001566433,0.0001178314,0.00003928509,0.0001030742,0.00004523938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001099458,0.0001320478,0.269702,0.0002985524,0.0002102952,0.0001855375,0.0001188742,0.006103966,0.6650531,0.0001858717,0.0009558956,0.05595423],"study_design_scores_gemma":[0.00005754912,0.0008421195,0.4593857,0.00005819125,0.0002701736,0.001137541,0.0001798929,0.120884,0.4122186,0.001133267,0.003762754,0.00007024736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558964,0.001465028,0.03747258,0.0002046387,0.00002860562,0.00007525417,0.003737064,0.0004778921,0.0006424292],"genre_scores_gemma":[0.9754454,0.0002698409,0.02103523,0.0001570117,0.00002322385,0.0000732054,0.00239565,0.00002767261,0.0005727728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145334,"threshold_uncertainty_score":0.003831506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0168205049275744,"score_gpt":0.2437798969086696,"score_spread":0.2269593919810952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}