{"id":"W4403057891","doi":"10.1055/s-0044-1789692","title":"Efficacy and safety of mirikizumab as induction and maintenance therapy in patients with moderately to severely active Crohn’s disease: Summary results from the Phase 3 VIVID-1 trial","year":2024,"lang":"en","type":"article","venue":"Zeitschrift für Gastroenterologie","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Hospital; Western University","funders":"","keywords":"Crohn's disease; Disease; Maintenance therapy; Medicine; Phase (matter); Internal medicine; Chemotherapy; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000180481,0.0002344256,0.0001900524,0.00005399518,0.00006863406,0.0000514941,0.0001611299,0.00009053273,0.000004970282],"category_scores_gemma":[0.000225996,0.0001573926,0.0000476251,0.00007186541,0.0001650064,0.00002508807,0.0001393894,0.0001660825,0.000001860936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001129896,"about_ca_system_score_gemma":0.0001134992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004795935,"about_ca_topic_score_gemma":0.0000635007,"domain_scores_codex":[0.9984358,0.0001916803,0.0003117876,0.0005904799,0.0001764744,0.0002938061],"domain_scores_gemma":[0.9992718,0.00005816622,0.00008939856,0.000350866,0.00008000208,0.0001497458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9831171,0.000371312,0.005563983,0.00001564082,0.0001544978,0.00009248556,0.0002543496,0.0001278688,0.0008084442,0.00001795142,0.0007666381,0.008709709],"study_design_scores_gemma":[0.05463454,0.002376745,0.9400999,0.0001151628,0.00003317784,0.000001170897,0.00005035862,0.00004896385,0.0005930786,0.00001484071,0.001905542,0.000126514],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966177,0.000202531,0.00009505257,0.0006314184,0.0001484278,0.001217583,0.001011241,0.00001977814,0.00005627135],"genre_scores_gemma":[0.9986712,0.0002106374,0.00008399472,0.0004576911,0.0001068095,0.000062769,0.0003565484,0.00002573441,0.00002460936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9345359,"threshold_uncertainty_score":0.6418282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234790119230313,"score_gpt":0.2718217446805332,"score_spread":0.25947384348823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}