{"id":"W4403057891","doi":"10.1055/s-0044-1789692","title":"Efficacy and safety of mirikizumab as induction and maintenance therapy in patients with moderately to severely active Crohn’s disease: Summary results from the Phase 3 VIVID-1 trial","year":2024,"lang":"en","type":"article","venue":"Zeitschrift für Gastroenterologie","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Hospital; Western University","funders":"","keywords":"Crohn's disease; Disease; Maintenance therapy; Medicine; Phase (matter); Internal medicine; Chemotherapy; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001503526,0.0007226246,0.002347987,0.0001850658,0.0002309526,0.0007966169,0.0004834666,0.0007204987,0.001364785],"category_scores_gemma":[0.00110309,0.0002434335,0.001332984,0.0002542696,0.0005120758,0.0007613102,0.0002339863,0.00253891,0.000310729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004718692,"about_ca_system_score_gemma":0.000449855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000373416,"about_ca_topic_score_gemma":0.000886902,"domain_scores_codex":[0.9996001,0.000215383,0.00002243525,0.00005344292,0.00003804387,0.00007069565],"domain_scores_gemma":[0.9993792,0.0001992087,0.0001557749,0.00004878031,0.00002218978,0.0001948391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7886767,0.003937057,0.007118433,0.001255319,0.003222047,0.0001138258,0.0001633408,0.001554651,0.01930469,0.0002974028,0.003629933,0.1707265],"study_design_scores_gemma":[0.6821512,0.215805,0.08458943,0.0002239663,0.003542624,0.00060893,0.0001062536,0.002035465,0.003916033,0.000807836,0.006122015,0.00009106869],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775206,0.01838344,0.0004156362,0.0007564361,0.0001616768,0.0002200541,0.0006987243,0.00008959066,0.001753831],"genre_scores_gemma":[0.9905707,0.004756077,0.0008285695,0.0007935329,0.000238741,0.0002924687,0.001481183,0.00002681496,0.00101196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002347987,"threshold_uncertainty_score":0.007951498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234790119230313,"score_gpt":0.2718217446805332,"score_spread":0.25947384348823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}