{"id":"W4403060086","doi":"10.1109/jbhi.2024.3472462","title":"Longitudinal Alzheimer's Disease Progression Prediction With Modality Uncertainty and Optimization of Information Flow","year":2024,"lang":"en","type":"article","venue":"IEEE Journal of Biomedical and Health Informatics","topic":"Artificial Intelligence in Healthcare","field":"Health Professions","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Chonnam National University Hwasun Hospital; Ministry of Science and ICT, South Korea; H. Lundbeck A/S; Servier; Iran Telecommunication Research Center; Eisai; Meso Scale Diagnostics; National Research Foundation of Korea; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; Northern California Institute for Research and Education; National Research Foundation; IXICO; Takeda Pharmaceutical Company; Institute for Information and Communications Technology Promotion; Pfizer; Biogen; BioClinica; Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Drug Discovery Foundation; Genentech; Chonnam National University; Alzheimer's Association","keywords":"Computer science; Information flow; Modality (human–computer interaction); Disease; Flow (mathematics); Artificial intelligence; Medicine; Internal medicine; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001889802,0.0007814019,0.001061799,0.0007433783,0.0003746542,0.0009138589,0.0009863696,0.001105142,0.0006689449],"category_scores_gemma":[0.003990218,0.0004424744,0.0009837301,0.0005726227,0.0005543362,0.001417137,0.0007900478,0.001442887,0.0001502676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001038599,"about_ca_system_score_gemma":0.001202904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01181275,"about_ca_topic_score_gemma":0.009248017,"domain_scores_codex":[0.999613,0.0001146302,0.0000227163,0.0001419081,0.00004673586,0.00006104668],"domain_scores_gemma":[0.9986774,0.0009131131,0.0001439165,0.0000647646,0.0001389921,0.00006179357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002479492,0.0001263126,0.004997392,0.00004390916,0.00007743811,0.0001152372,0.00009613471,0.9228872,0.001967203,0.002566547,0.001009892,0.0658648],"study_design_scores_gemma":[0.000003299072,0.00001950119,0.0002754271,0.000002838769,0.000009289574,0.000009753028,0.000003150119,0.9979886,0.0002189863,0.001394391,0.00007071892,0.000004059708],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2447317,0.001740224,0.7491456,0.00141723,0.00007182467,0.00007674552,0.0005132371,0.0008523204,0.001451196],"genre_scores_gemma":[0.9587113,0.0003376798,0.03903164,0.0001716703,0.00005928943,0.0000770984,0.0002975833,0.00003442238,0.001279207],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01181275,"threshold_uncertainty_score":0.02348799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1015329781603014,"score_gpt":0.4408519201258749,"score_spread":0.3393189419655735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}