{"id":"W4403081341","doi":"10.1053/j.gastro.2024.09.030","title":"Safety and Tolerability of CP101, a Full-Spectrum, Oral Microbiome Therapeutic for the Prevention of Recurrent Clostridioides difficile Infection: A Phase 2 Randomized Controlled Trial","year":2024,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Calgary Laboratory Services; University Health Network; Dalhousie University; St Joseph's Health Care; Western University; University of Calgary","funders":"","keywords":"Tolerability; Medicine; Randomized controlled trial; Microbiome; Clostridium difficile; Internal medicine; Adverse effect; Microbiology; Antibiotics; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001919933,0.002034007,0.003517273,0.0004857271,0.0005299579,0.001821059,0.001026429,0.002658455,0.008071351],"category_scores_gemma":[0.002111845,0.0008036164,0.002668944,0.0005773726,0.001546862,0.001674521,0.0004049296,0.004187357,0.001168642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000823059,"about_ca_system_score_gemma":0.001337433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008321152,"about_ca_topic_score_gemma":0.001244704,"domain_scores_codex":[0.9990606,0.0004303818,0.00005820114,0.000197564,0.00008640427,0.0001669681],"domain_scores_gemma":[0.9986913,0.0004583955,0.0002737702,0.0001040287,0.00009235977,0.0003800912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9740582,0.005102213,0.0003893777,0.0006485059,0.001070597,0.00003978722,0.00003150957,0.0002564432,0.002134116,0.00008584776,0.0006038168,0.0155795],"study_design_scores_gemma":[0.9070541,0.08889771,0.001616127,0.0000567949,0.0008676417,0.00004687325,0.00002866168,0.0004022992,0.0004449085,0.0001134214,0.000448635,0.0000227795],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821721,0.008418389,0.001092284,0.0008036944,0.0006067063,0.002621329,0.001392793,0.0001657903,0.002726847],"genre_scores_gemma":[0.9870217,0.003868381,0.001236349,0.001309828,0.0005009756,0.002443155,0.001416887,0.0000403232,0.0021623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008071351,"threshold_uncertainty_score":0.02700138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02578662750648364,"score_gpt":0.3398131923797949,"score_spread":0.3140265648733113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}