{"id":"W4403083187","doi":"10.1007/s00415-024-12700-x","title":"A 14-year longitudinal study of neurofilament light chain dynamics in premanifest and transitional Huntington’s disease","year":2024,"lang":"en","type":"article","venue":"Journal of Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Cambridge Centre for Parkinson-Plus; Alzheimer’s Research UK; Guarantors of Brain; UK Research and Innovation; Cure Parkinson's Trust; NIHR Cambridge Biomedical Research Centre; Wellcome Trust","keywords":"Neurology; Cohort; Medicine; Biomarker; Internal medicine; Huntington's disease; Montreal Cognitive Assessment; Psychology; Disease; Oncology; Cardiology; Neuroscience; Dementia; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009989158,0.0003164043,0.000376507,0.000857035,0.0008296802,0.0005467695,0.0003240634,0.0005535798,0.000759995],"category_scores_gemma":[0.001501728,0.0002618546,0.0003338404,0.0005337974,0.0002778953,0.0005292068,0.0005463866,0.0006666525,0.0002860782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003302881,"about_ca_system_score_gemma":0.0003146587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006788922,"about_ca_topic_score_gemma":0.005106442,"domain_scores_codex":[0.9996904,0.00007647651,0.00002632044,0.00008346084,0.00004833757,0.00007493926],"domain_scores_gemma":[0.9990309,0.0001068169,0.0002349677,0.00009859933,0.0002286143,0.0003000088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005920128,0.0002462525,0.9962851,0.000003975406,0.00004739948,0.0001582788,0.0002504564,0.00002762412,0.0006325367,0.00001248745,0.00007183537,0.00167197],"study_design_scores_gemma":[0.000009712626,0.0004678262,0.9988686,0.000002228886,0.0000212483,0.0001718009,0.0001253694,0.00008753627,0.00009128185,0.00001374732,0.0001368802,0.000003625493],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996231,0.0000595926,0.00004945619,0.000009520796,0.000002660249,0.000005858923,0.0001365219,0.000002310806,0.0001109173],"genre_scores_gemma":[0.9989858,0.00003712218,0.00008016028,0.0000143499,0.00000414707,0.00001091318,0.0005787685,0.000001474698,0.0002872663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006788922,"threshold_uncertainty_score":0.01349878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02299051336958835,"score_gpt":0.2769539587211007,"score_spread":0.2539634453515123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}