{"id":"W4403087630","doi":"10.1016/s0140-6736(24)01556-3","title":"Effects of oral sepiapterin on blood Phe concentration in a broad range of patients with phenylketonuria (APHENITY): results of an international, phase 3, randomised, double-blind, placebo-controlled trial","year":2024,"lang":"en","type":"article","venue":"The Lancet","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Placebo; Double blind; Medicine; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001122129,0.001958074,0.004393212,0.0004078325,0.0004686021,0.001070512,0.0008876696,0.00240764,0.003932057],"category_scores_gemma":[0.001486608,0.0007017172,0.002237509,0.0004603085,0.001217431,0.001126573,0.000383199,0.00348528,0.0006949042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005214695,"about_ca_system_score_gemma":0.0006505595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117998,"about_ca_topic_score_gemma":0.001767701,"domain_scores_codex":[0.9995826,0.0001689311,0.00003686381,0.00009192071,0.00003602407,0.0000837846],"domain_scores_gemma":[0.999114,0.0003212771,0.0001333467,0.00005834808,0.00004856677,0.0003244404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9845035,0.002305241,0.0004969091,0.0004477124,0.0009258366,0.00005700711,0.00003471126,0.0001377368,0.002304122,0.00003062288,0.0002926187,0.008463849],"study_design_scores_gemma":[0.9434271,0.05203515,0.003106424,0.00002512936,0.0005522766,0.00003926594,0.00002193273,0.0001881071,0.0003219182,0.00006578536,0.0002012936,0.00001558488],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902636,0.005959206,0.0003981349,0.0004332061,0.0003399643,0.0007010474,0.0005309101,0.0001249697,0.001248993],"genre_scores_gemma":[0.9917293,0.003389628,0.0007133126,0.0007677413,0.0003575989,0.0008246711,0.000710195,0.0000230524,0.001484453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004393212,"threshold_uncertainty_score":0.01315403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387744055835434,"score_gpt":0.2906890010719871,"score_spread":0.2768115605136328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}