{"id":"W4403087827","doi":"10.1016/j.lanhl.2024.07.013","title":"Challenges in the practical implementation of blood biomarkers for Alzheimer’s disease","year":2024,"lang":"en","type":"review","venue":"The Lancet Healthy Longevity","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Novo Nordisk; Alzheimer's Association","keywords":"Medicine; Disease; Biomarker; Intensive care medicine; Referral; Population; Pathology; Family medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002126193,0.0003364932,0.001412277,0.0001387517,0.00009695167,0.00002658582,0.0002759956,0.000115785,0.00002545622],"category_scores_gemma":[0.0001689442,0.0001570966,0.0005004976,0.0003173179,0.0001423514,0.00006062058,0.00008079079,0.0005095754,0.00003767286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008244751,"about_ca_system_score_gemma":0.00183402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001135503,"about_ca_topic_score_gemma":0.0001914772,"domain_scores_codex":[0.9969409,0.0008515623,0.0006059823,0.0004719563,0.0005398468,0.0005898181],"domain_scores_gemma":[0.997365,0.001082577,0.0002742158,0.0009330495,0.00006737166,0.0002777604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009157704,0.0008930226,0.0002450282,0.05414212,0.01540005,0.0002485797,0.0002296633,1.308602e-8,1.276719e-8,0.001786405,0.004441615,0.9216977],"study_design_scores_gemma":[0.005672811,0.002097384,0.009386096,0.01437315,0.122583,0.0002671447,0.0009979338,0.00001382056,0.000001189862,0.001846624,0.8422342,0.0005266892],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007067154,0.9698992,0.000001033097,0.0230972,0.00009832576,0.005908759,0.0007025031,0.0000287783,0.0001934652],"genre_scores_gemma":[0.003833637,0.9931942,0.00008853287,0.0002470655,0.0005360666,0.001620446,0.0004316334,0.00004668291,0.000001753104],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.921171,"threshold_uncertainty_score":0.6406213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4212026513751417,"score_gpt":0.5455135147213802,"score_spread":0.1243108633462385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}