{"id":"W4403089975","doi":"10.1200/jco.2022.40.16_suppl.6005","title":"ROMAN: Phase 3 trial of avasopasem manganese (GC4419) for severe oral mucositis (SOM) in patients receiving chemoradiotherapy (CRT) for locally advanced, nonmetastatic head and neck cancer (LAHNC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Oral health in cancer treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Northeast Cancer Centre; Health Sciences North; Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec","funders":"","keywords":"Mucositis; Medicine; Head and neck cancer; Chemoradiotherapy; Head and neck; Internal medicine; Cancer; Oncology; Surgery; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001340182,0.001614445,0.002111469,0.0006056426,0.0005726047,0.001176308,0.001518719,0.002064295,0.01667565],"category_scores_gemma":[0.001176261,0.0006774146,0.001921169,0.0005141351,0.001037254,0.0009759668,0.000518687,0.004084214,0.003011635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009627439,"about_ca_system_score_gemma":0.001997021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001301557,"about_ca_topic_score_gemma":0.003842104,"domain_scores_codex":[0.9996094,0.000202138,0.00001308259,0.00006936039,0.00003767741,0.00006831437],"domain_scores_gemma":[0.9995106,0.00007812218,0.0001062955,0.00005369222,0.00003844884,0.0002127376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8803328,0.03038817,0.00134344,0.001541161,0.001161809,0.0001189228,0.0001295584,0.001093672,0.01290879,0.0003912255,0.008510262,0.0620801],"study_design_scores_gemma":[0.9020693,0.09231354,0.001844823,0.00004857308,0.0002181951,0.00007791881,0.00002315307,0.0004027095,0.000579831,0.0001991781,0.002208053,0.00001476435],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550533,0.00765372,0.001387386,0.002348359,0.0009133519,0.0143332,0.006469089,0.0008007696,0.01104087],"genre_scores_gemma":[0.9443982,0.005760917,0.004733273,0.004719915,0.0004888721,0.01655818,0.007808025,0.000173966,0.01535866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01667565,"threshold_uncertainty_score":0.0557856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1276608658609772,"score_gpt":0.5254101535742833,"score_spread":0.3977492877133061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}