{"id":"W4403090002","doi":"10.1200/jco.2022.40.16_suppl.6046","title":"Results of ACCURACY: A phase 2 trial of AL101, a selective gamma secretase inhibitor, in subjects with recurrent/metastatic (R/M) adenoid cystic carcinoma (ACC) harboring Notch activating mutations (Notch <sup>mut</sup> ).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Juravinski Cancer Centre; Western University","funders":"","keywords":"Medicine; Notch signaling pathway; Adenoid cystic carcinoma; Gamma secretase; Pathology; Internal medicine; Cancer research; Oncology; Carcinoma; Receptor; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003640727,0.002008687,0.002065039,0.0005579407,0.0004164919,0.001066883,0.001028938,0.002127803,0.005206725],"category_scores_gemma":[0.002059121,0.0005984911,0.001294635,0.0004266538,0.001039162,0.001389327,0.0004807656,0.003060317,0.001881531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008195794,"about_ca_system_score_gemma":0.001196703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008302171,"about_ca_topic_score_gemma":0.002057794,"domain_scores_codex":[0.9989129,0.0006126077,0.00005954913,0.0001433151,0.000102525,0.0001690655],"domain_scores_gemma":[0.9983916,0.0003653197,0.0003556998,0.0001459703,0.0001941361,0.0005472536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8700777,0.02452693,0.00884912,0.0007099406,0.001657329,0.0002761943,0.0003455222,0.001740647,0.01460114,0.0002648708,0.008217948,0.06873253],"study_design_scores_gemma":[0.6978546,0.274143,0.01625144,0.00005900396,0.001230849,0.0003806021,0.00006153031,0.001448036,0.002169002,0.0002241515,0.006130826,0.00004692793],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795063,0.004978447,0.0008619559,0.001389523,0.0003533965,0.002899167,0.003584185,0.0003108367,0.006116174],"genre_scores_gemma":[0.9761179,0.002605119,0.002649745,0.002581446,0.0005273658,0.002587798,0.007881045,0.00008406366,0.004965534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005206725,"threshold_uncertainty_score":0.01925421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07298259955231844,"score_gpt":0.4292673237034095,"score_spread":0.3562847241510911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}