{"id":"W4403090586","doi":"10.1101/2024.10.01.616157","title":"TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"BC Children's Hospital","keywords":"Function (biology); Immunology; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001420173,0.0003627989,0.0003280678,0.0001702871,0.0001170866,0.0003426344,0.0001552288,0.0002083206,0.003081797],"category_scores_gemma":[0.00007954669,0.00009235629,0.0002308311,0.0001355813,0.0001541148,0.0001669182,0.0001432162,0.0006536243,0.0005664221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000178339,"about_ca_system_score_gemma":0.0002323151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004396652,"about_ca_topic_score_gemma":0.0006957829,"domain_scores_codex":[0.9998406,0.00002656757,0.00002139439,0.00002379717,0.0000387367,0.00004887158],"domain_scores_gemma":[0.9999267,0.00001238677,0.00001780658,0.00001051856,0.000009358296,0.00002325004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009146181,0.0001058382,0.0002395902,0.0001017125,0.00001278165,0.00004693765,0.000007151723,0.0001234989,0.993929,0.00006530303,0.0002387793,0.004214789],"study_design_scores_gemma":[0.0001175783,0.0008891585,0.002756009,0.000006393429,0.00002777717,0.0002215013,0.00001526686,0.0006372036,0.9921117,0.0000282119,0.003184299,0.000004891794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907427,0.004045399,0.001095698,0.0001834583,0.0001222888,0.00003307813,0.0006986154,0.000127061,0.002951693],"genre_scores_gemma":[0.9937982,0.0011914,0.0008767832,0.00007855054,0.00003060551,0.00003365239,0.0005852774,0.00002082454,0.003384781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003081797,"threshold_uncertainty_score":0.01030964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112875462182766,"score_gpt":0.2213104643747076,"score_spread":0.2101817097528799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}