{"id":"W4403091795","doi":"10.1038/s41420-024-02152-7","title":"TRIB3 inhibition by palbociclib sensitizes prostate cancer to ferroptosis via downregulating SOX2/SLC7A11 expression","year":2024,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Palbociclib; Prostate cancer; SOX2; Cancer; Cancer research; Apoptosis; Prostate; Medicine; Internal medicine; Chemistry; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009436043,0.0002793065,0.0002824027,0.0001895617,0.0002194789,0.0003286172,0.0001853404,0.0002254413,0.002110324],"category_scores_gemma":[0.00006662446,0.00008323696,0.0002550135,0.0001829987,0.0002187012,0.0001292746,0.0001335721,0.0008050274,0.0003495819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004582871,"about_ca_system_score_gemma":0.0004094162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001470223,"about_ca_topic_score_gemma":0.004400249,"domain_scores_codex":[0.9999243,0.000009354221,0.000004831074,0.00001366723,0.00002170736,0.00002606086],"domain_scores_gemma":[0.9999641,0.000004413559,0.000006614821,0.000003722165,0.000008522387,0.0000126886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003179747,0.0001194334,0.0007679868,0.0001696169,0.00002067478,0.0001667139,0.00002627673,0.0002258019,0.9854064,0.0002722559,0.0009886174,0.01151827],"study_design_scores_gemma":[0.0001447077,0.0008878485,0.006032532,0.00001394694,0.00003813658,0.0008372027,0.00006877368,0.001580419,0.9710177,0.0001616432,0.01920636,0.00001073567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708584,0.01081643,0.006483258,0.001097131,0.0001846863,0.0001605095,0.001234004,0.0004849891,0.00868063],"genre_scores_gemma":[0.9917535,0.002257517,0.001427582,0.0002438604,0.00001805543,0.00005011898,0.0007570368,0.00002650006,0.003465789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002110324,"threshold_uncertainty_score":0.007059753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697873924924086,"score_gpt":0.3053688328334792,"score_spread":0.2883900935842383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}