{"id":"W4403092346","doi":"10.1126/science.adn4955","title":"A multivalent mRNA-LNP vaccine protects against <i>Clostridioides difficile</i> infection","year":2024,"lang":"en","type":"article","venue":"Science","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada); Polytechnique Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Children's Hospital of Philadelphia","keywords":"Clostridioides; Virology; Microbiology; Messenger RNA; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000110788,0.0003543914,0.000226358,0.0001537507,0.0001099663,0.0001901062,0.0001431135,0.0003015041,0.0007645254],"category_scores_gemma":[0.0001031514,0.00006949572,0.0001631301,0.00006065788,0.0001938897,0.0001813654,0.0001717832,0.0004333602,0.0001765945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002108611,"about_ca_system_score_gemma":0.0002375784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003300674,"about_ca_topic_score_gemma":0.0004607996,"domain_scores_codex":[0.9999141,0.000009221644,0.000004825039,0.00002166042,0.00002050582,0.0000297669],"domain_scores_gemma":[0.9999559,0.00000573182,0.00001650105,0.000003373769,0.000008107535,0.00001047257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009335908,0.00007593124,0.0001057366,0.00006161979,0.000004651405,0.00003918395,0.00001155233,0.0002154256,0.9933401,0.0001245697,0.0001013655,0.005826513],"study_design_scores_gemma":[0.00005639669,0.003721097,0.001487751,0.00002101842,0.00004975875,0.0003372934,0.00003765431,0.001778739,0.9871863,0.0001001916,0.005214993,0.00000881915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987209,0.001474035,0.009093111,0.0002354571,0.0001279122,0.00006404425,0.00009053265,0.0001701339,0.001535759],"genre_scores_gemma":[0.9919797,0.000856219,0.004456356,0.0001300437,0.00003008561,0.00004194445,0.0001668789,0.00002231642,0.002316486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007645254,"threshold_uncertainty_score":0.002557576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391652453235475,"score_gpt":0.322533296504424,"score_spread":0.2986167719720693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}