{"id":"W4403092551","doi":"10.1093/clinchem/hvae144","title":"Alzheimer Disease Blood-Based Biomarkers: Translation from Research into Clinical Use","year":2024,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Providence Health Care","funders":"","keywords":"Disease; Medicine; Translation (biology); Alzheimer's disease; Pathology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04341742,0.001464461,0.002202889,0.003069094,0.0005639008,0.00834603,0.002184054,0.004933067,0.006565773],"category_scores_gemma":[0.08041175,0.000873642,0.0009714693,0.003102044,0.005534099,0.008633131,0.003596071,0.008220661,0.003516791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004777639,"about_ca_system_score_gemma":0.009196896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003072903,"about_ca_topic_score_gemma":0.001569116,"domain_scores_codex":[0.9881322,0.004183806,0.001625378,0.001523978,0.004115517,0.000419193],"domain_scores_gemma":[0.9360338,0.03507067,0.003978086,0.003234759,0.01842174,0.003260942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004926094,0.0002909645,0.005430014,0.004803588,0.000173833,0.0002584512,0.0005045299,0.0009742368,0.003274068,0.06848653,0.05965932,0.8556519],"study_design_scores_gemma":[0.0002671301,0.001849547,0.01587752,0.01708302,0.0003061844,0.001196962,0.001445075,0.003487146,0.004932157,0.1603128,0.7930139,0.0002285593],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006696152,0.754836,0.03327407,0.1711791,0.01038469,0.0003728182,0.001392434,0.0007214969,0.02114322],"genre_scores_gemma":[0.0951544,0.7653253,0.06557734,0.0531184,0.01437742,0.0008039826,0.00132259,0.0002904693,0.004030201],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.04341742,"threshold_uncertainty_score":0.229616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3866937312720131,"score_gpt":0.5333916607969175,"score_spread":0.1466979295249043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}