{"id":"W4403097533","doi":"10.1158/1055-9965.epi-24-0926","title":"Plasma Ghrelin and Risks of Sex-Specific, Site-Specific, and Early-Onset Colorectal Cancer: A Mendelian Randomization Analysis","year":2024,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Health Sciences","funders":"Swedish Cancer Foundation; National Institute of Environmental Health Sciences; National Institute on Aging; Univerzita Karlova v Praze; McGill University; Generalitat de Catalunya; NIHR Imperial Biomedical Research Centre; European Cooperation in Science and Technology; National Cancer Institute; European Regional Development Fund; National Human Genome Research Institute; Cancer Council Victoria; Ontario Ministry of Research and Innovation; Deutsche Krebshilfe; National Health and Medical Research Council; Medical Research Council; Knut och Alice Wallenbergs Stiftelse; Canadian Institutes of Health Research; National Institute for Health and Care Research; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Junta de Castilla y León; Moffitt Cancer Center; Umeå Universitet; Stockholm läns landsting; Xunta de Galicia; World Cancer Research Fund; Region Skåne; Florida Department of Health; National Institutes of Health; Division of Cancer Prevention, National Cancer Institute; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Association Anne de Bretagne Genetique; Centre Hospitalier Universitaire de Nantes; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Frauen; School of Public Health, Imperial College London; Karolinska Institutet; Associazione Italiana per la Ricerca sul Cancro; Conseil Régional des Pays de la Loire; Vetenskapsrådet; Stockholms Läns Landsting; National Institute of Diabetes and Digestive and Kidney Diseases; American Institute for Cancer Research; Ministerstvo Zdravotnictví Ceské Republiky; Ligue Contre le Cancer; Federación Española de Enfermedades Raras; Cancerfonden; Fundación Científica Asociación Española Contra el Cáncer; University of Cambridge; Génome Québec; ZonMw; Institut Gustave-Roussy; Herzfelder'sche Familienstiftung; Grantová Agentura České Republiky; Canadian Cancer Society Research Institute; Marshfield Clinic Research Foundation; Institut National de la Santé et de la Recherche Médicale; Damon Runyon Cancer Research Foundation; University of Bristol; Imperial College London; Food Standards Agency; Chonnam National University; Centres de Recerca de Catalunya; Office of Research Infrastructure Programs, National Institutes of Health; State of Maryland; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Danish Cancer Society Research Center; KWF Kankerbestrijding; National Research Council; Wereld Kanker Onderzoek Fonds; Brigham and Women's Hospital; Center for Strategic Scientific Initiatives, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; Harvard T.H. Chan School of Public Health; Victorian Cancer Agency; Johns Hopkins University; Canadian Cancer Society; Memorial Sloan-Kettering Cancer Center; Pelotonia; Deutsches Krebsforschungszentrum; Ministerio de Economía y Competitividad; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; University of South Florida; Transcan; Biobanco Vasco; Fred Hutchinson Cancer Research Center; Wageningen University and Research; Cancer Research UK; VicHealth; Emory University; U.S. Department of Health and Human Services; Instituto de Salud Carlos III; National Heart, Lung, and Blood Institute; Ohio State University; American Cancer Society; Mike and Josie Harper Cancer Research Institute","keywords":"Mendelian randomization; Ghrelin; Oncology; Colorectal cancer; Medicine; Internal medicine; Cancer; Confidence interval; Genome-wide association study; Meta-analysis; Endocrinology; Genetics; Biology; Genotype; Hormone; Genetic variants; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04516496,0.001617958,0.002501866,0.001621741,0.0006051678,0.0009059946,0.001595796,0.001426947,0.004142465],"category_scores_gemma":[0.07428492,0.0007381204,0.007470441,0.001222821,0.00127846,0.0007535568,0.0008553956,0.001098595,0.0002760758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008072997,"about_ca_system_score_gemma":0.001023819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002160013,"about_ca_topic_score_gemma":0.001186814,"domain_scores_codex":[0.9424753,0.04685836,0.001895571,0.005695521,0.002330233,0.0007450244],"domain_scores_gemma":[0.9430968,0.04339693,0.005126094,0.006950206,0.0009950076,0.00043512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1375734,0.001029341,0.5386661,0.003412853,0.1621134,0.004338354,0.0009385539,0.02392217,0.0119395,0.02110988,0.005828664,0.08912782],"study_design_scores_gemma":[0.04150779,0.0290377,0.4252281,0.0007859464,0.1703912,0.01010678,0.00041475,0.2538593,0.009274243,0.0466051,0.01214778,0.0006412854],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8496587,0.008810326,0.1343812,0.001005322,0.0003377926,0.001796554,0.001626156,0.0005893509,0.001794626],"genre_scores_gemma":[0.9661787,0.0004753158,0.03103104,0.0002963586,0.00007109751,0.0009970756,0.0004251842,0.0000480003,0.0004772629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04516496,"threshold_uncertainty_score":0.238858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07506468675980073,"score_gpt":0.3609365100004303,"score_spread":0.2858718232406295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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