{"id":"W4403098425","doi":"10.1021/acs.chemrestox.4c00265","title":"The Interaction of Myeloperoxidase with the Industrial Contaminant 6-PPD: A Potential Pathway for Reactive Metabolites","year":2024,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Myeloperoxidase; Chemistry; Biochemistry; Inflammation; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003528814,0.0007411393,0.0003028437,0.0003035716,0.0002037065,0.0003717491,0.0003367205,0.0008932465,0.0008321933],"category_scores_gemma":[0.0003278549,0.0002335481,0.0005080533,0.0002257413,0.0002605511,0.0005423219,0.0004352646,0.0005927815,0.0002927076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002766758,"about_ca_system_score_gemma":0.0001917311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000308631,"about_ca_topic_score_gemma":0.0002377406,"domain_scores_codex":[0.9996879,0.00008574259,0.00001865134,0.00006361314,0.0000734897,0.00007048064],"domain_scores_gemma":[0.9997757,0.00004137989,0.00007509527,0.00002021177,0.00005450963,0.00003309994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001833741,0.00006134782,0.001442394,0.0002463569,0.00003643386,0.0005015836,0.00005769088,0.0001241449,0.9936656,0.0002490125,0.00008305736,0.003348858],"study_design_scores_gemma":[0.000008197625,0.0004065149,0.00282438,0.00001582192,0.00002648877,0.0005824543,0.00004789379,0.0008056652,0.9919928,0.0001815514,0.003100203,0.000008092282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610909,0.01583176,0.01920919,0.00069154,0.0001301298,0.0001722236,0.0004641877,0.0001119077,0.002298193],"genre_scores_gemma":[0.9871497,0.00337027,0.006917387,0.0001991727,0.00003911991,0.00005429506,0.00032371,0.00001123598,0.001935343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008932465,"threshold_uncertainty_score":0.002784014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07653356111190347,"score_gpt":0.3498568934765416,"score_spread":0.2733233323646382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}