{"id":"W4403101316","doi":"10.1002/mds.30028","title":"Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology","year":2024,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Michael's Hospital; Ottawa Hospital; University of Ottawa; Occupational Cancer Research Centre; University of Toronto","funders":"National Institute of Mental Health; National Health and Medical Research Council; Medical Research Council; National Center of Neurology and Psychiatry; Parkinson Canada; Universitetet i Oslo; Krembil Foundation; Eisai; Fonds National de la Recherche Luxembourg; Eli Lilly and Company; University of Auckland; European Commission; Japan Society for the Promotion of Science; Imperial College London; Vlaamse regering; University of Oxford; Parkinson's UK; National Institute on Aging; National Institute for Health and Care Research; National Institute of Neurological Disorders and Stroke; Andrew W. Mellon Foundation; University of Pittsburgh; University of Cambridge; Multiple System Atrophy Coalition; Alzheimer Forschung Initiative; Pfizer; Biogen; Fonds Wetenschappelijk Onderzoek; Noyce Foundation; Deutsche Forschungsgemeinschaft; Japan Agency for Medical Research and Development; National Institutes of Health; Association for Frontotemporal Degeneration; Public Health Agency; Alzheimer's Drug Discovery Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neuropathology; Synucleinopathies; Biomarker; Neuroscience; Medicine; Psychology; Parkinson's disease; Pathology; Disease; Biology; Alpha-synuclein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01028351,0.001939498,0.00242568,0.005044172,0.001032055,0.004096881,0.004417357,0.007391771,0.002609243],"category_scores_gemma":[0.01221582,0.0007753493,0.001217413,0.001986396,0.01521488,0.01461356,0.004063129,0.01271584,0.001429918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003942041,"about_ca_system_score_gemma":0.002677781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002190642,"about_ca_topic_score_gemma":0.001576441,"domain_scores_codex":[0.9984096,0.0006217504,0.0001874934,0.0002572628,0.0004123192,0.0001116727],"domain_scores_gemma":[0.9884881,0.00675662,0.0004630214,0.00101184,0.002469975,0.0008103951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002996612,0.0004932466,0.004395354,0.004775862,0.0003097153,0.002074294,0.001154362,0.007673744,0.00482638,0.4764524,0.05093753,0.4466075],"study_design_scores_gemma":[0.00005520144,0.0003235838,0.001693648,0.002022831,0.00007391907,0.001644988,0.000549454,0.00487894,0.001945775,0.8071309,0.179522,0.0001587586],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00394757,0.8054932,0.0629923,0.1119398,0.006839216,0.00006761786,0.0001407514,0.0002870538,0.008292488],"genre_scores_gemma":[0.08678978,0.7527674,0.08369178,0.03934591,0.03325674,0.0002277485,0.0001808338,0.0002015914,0.003538229],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01028351,"threshold_uncertainty_score":0.05438507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02786843743252639,"score_gpt":0.2897279851897115,"score_spread":0.2618595477571852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}