{"id":"W4403101316","doi":"10.1002/mds.30028","title":"Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology","year":2024,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Michael's Hospital; Ottawa Hospital; University of Ottawa; Occupational Cancer Research Centre; University of Toronto","funders":"National Institute of Mental Health; National Health and Medical Research Council; Medical Research Council; National Center of Neurology and Psychiatry; Parkinson Canada; Universitetet i Oslo; Krembil Foundation; Eisai; Fonds National de la Recherche Luxembourg; Eli Lilly and Company; University of Auckland; European Commission; Japan Society for the Promotion of Science; Imperial College London; Vlaamse regering; University of Oxford; Parkinson's UK; National Institute on Aging; National Institute for Health and Care Research; National Institute of Neurological Disorders and Stroke; Andrew W. Mellon Foundation; University of Pittsburgh; University of Cambridge; Multiple System Atrophy Coalition; Alzheimer Forschung Initiative; Pfizer; Biogen; Fonds Wetenschappelijk Onderzoek; Noyce Foundation; Deutsche Forschungsgemeinschaft; Japan Agency for Medical Research and Development; National Institutes of Health; Association for Frontotemporal Degeneration; Public Health Agency; Alzheimer's Drug Discovery Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neuropathology; Synucleinopathies; Biomarker; Neuroscience; Medicine; Psychology; Parkinson's disease; Pathology; Disease; Biology; Alpha-synuclein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010118,0.000258138,0.0002687294,0.0002412593,0.00008646224,0.00005915954,0.0001125611,0.00007262481,0.0002235228],"category_scores_gemma":[0.00002723299,0.0002214266,0.0001706426,0.0003430106,0.00004148865,0.00005192237,0.00006451709,0.0001108707,0.0003030919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001111371,"about_ca_system_score_gemma":0.00008824662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002266795,"about_ca_topic_score_gemma":0.00002507187,"domain_scores_codex":[0.9983944,0.00005760181,0.0002084222,0.0006818348,0.0002945089,0.0003631896],"domain_scores_gemma":[0.9992399,0.00004035224,0.00002467688,0.0004108672,0.00001938413,0.0002647753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002195103,0.01494898,0.05275957,0.001427192,0.002746192,0.003364689,0.002955404,0.0005411182,0.1175733,0.02580284,0.07538284,0.7003028],"study_design_scores_gemma":[0.01074384,0.002542215,0.4658713,0.0008198938,0.002179781,0.000005980063,0.001817576,0.08457354,0.008103419,0.05085622,0.3706526,0.001833628],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8912539,0.003044731,0.05719433,0.01902032,0.001080562,0.001758943,0.0005105461,0.0007845851,0.02535201],"genre_scores_gemma":[0.9857562,0.00007602578,0.00265784,0.01045258,0.00004895698,0.00024117,0.0002350738,0.00006429726,0.000467906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6984692,"threshold_uncertainty_score":0.9029515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02786843743252639,"score_gpt":0.2897279851897115,"score_spread":0.2618595477571852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}