{"id":"W4403105058","doi":"10.1101/2024.10.01.614851","title":"Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital; University of Toronto","funders":"","keywords":"Frontotemporal dementia; Dementia; Psychology; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001432861,0.0003501521,0.0007550368,0.0002075019,0.00003943191,0.00007359119,0.0003556316,0.0003911203,0.00005954536],"category_scores_gemma":[0.0001509964,0.0002605218,0.0003551543,0.0002791765,0.0001798517,0.00002822043,0.0003051907,0.0008458772,0.00003122766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005350568,"about_ca_system_score_gemma":0.0006984776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002675101,"about_ca_topic_score_gemma":0.00004292496,"domain_scores_codex":[0.9972534,0.0002787777,0.0009121699,0.0006987415,0.000538821,0.0003181202],"domain_scores_gemma":[0.9984528,0.00009690879,0.0002731802,0.0009270618,0.000140987,0.000109068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001558586,0.001050616,0.9794025,0.002475969,0.001300768,0.0002493907,0.000226074,0.00001184768,0.01323355,0.0009018662,0.0009085442,0.00008303381],"study_design_scores_gemma":[0.001131752,0.0001732699,0.9924238,0.0006872088,0.0007826554,6.120715e-8,0.00005532027,0.0006314287,0.003197283,0.00002790584,0.0005969187,0.0002923557],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934242,0.00366649,0.0003032813,0.0005305322,0.0009189641,0.000983551,0.00004825699,0.00006192246,0.00006280929],"genre_scores_gemma":[0.9976773,0.0004553415,0.001307521,0.00013923,0.0002568437,0.0001016232,8.435975e-7,0.00005193944,0.000009406642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01302136,"threshold_uncertainty_score":0.9999847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02502852415892831,"score_gpt":0.2756860746402462,"score_spread":0.2506575504813179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}