{"id":"W4403127979","doi":"10.7554/elife.100604.1.sa1","title":"Reviewer #2 (Public review): Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Retinopathy of Prematurity Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Sunnybrook Research Institute","keywords":"Wnt signaling pathway; Cell biology; Progenitor cell; Progenitor; Retinal; Flux (metallurgy); Cellular differentiation; Glycolysis; Cell; Biology; Signal transduction; Chemistry; Stem cell; Botany; Biochemistry; Gene; Metabolism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.003245571,0.001324979,0.004618274,0.0003263435,0.0002432579,0.0001619979,0.0005010803,0.0005787021,0.003630859],"category_scores_gemma":[0.007790229,0.0009781556,0.001616688,0.0007229535,0.0001444219,0.000146139,0.0004505981,0.002030828,0.001102801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005665418,"about_ca_system_score_gemma":0.0004969276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000275866,"about_ca_topic_score_gemma":0.00001840249,"domain_scores_codex":[0.9914402,0.0005910284,0.002970018,0.001658536,0.002342611,0.0009975769],"domain_scores_gemma":[0.9922957,0.0004390466,0.001495066,0.00142947,0.003906804,0.000433873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001975157,0.0001022359,0.00001863137,0.2872722,0.0003629863,0.0000463183,0.00003272075,4.198291e-8,0.0006218718,0.00001152012,0.7014693,0.01004239],"study_design_scores_gemma":[0.0006446189,0.0002703813,0.00004899926,0.2886372,0.008273291,0.0001347538,0.00001078666,0.0001059915,0.000497936,0.00006525166,0.700569,0.0007418586],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.0001243116,0.8626629,0.00021343,0.1122514,0.005330717,0.0100266,0.00007994667,0.0004996267,0.008811147],"genre_scores_gemma":[0.002281737,0.3069254,0.002942635,0.01602791,0.008336015,0.002037902,0.00413887,0.0004013223,0.6569082],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.6480971,"threshold_uncertainty_score":0.9999502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03287279875674169,"score_gpt":0.3085150873041266,"score_spread":0.2756422885473849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}