{"id":"W4403127980","doi":"10.7554/elife.100604.1.sa2","title":"Reviewer #1 (Public review): Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Retinopathy of Prematurity Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Sunnybrook Research Institute","keywords":"Wnt signaling pathway; Cell biology; Progenitor cell; Retinal; Progenitor; Flux (metallurgy); Glycolysis; Cellular differentiation; Biology; Signal transduction; Chemistry; Stem cell; Endocrinology; Biochemistry; Gene; Metabolism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02146899,0.001562857,0.003189838,0.003568401,0.002736001,0.008664379,0.005976643,0.02090746,0.09687333],"category_scores_gemma":[0.1153348,0.001293565,0.003207879,0.00219176,0.002152524,0.004571759,0.003905725,0.008681335,0.05680503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006305085,"about_ca_system_score_gemma":0.01170158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003114464,"about_ca_topic_score_gemma":0.00490434,"domain_scores_codex":[0.9843833,0.003939837,0.002355166,0.001987196,0.00620132,0.001133244],"domain_scores_gemma":[0.8276815,0.01458572,0.008869792,0.004283817,0.1349762,0.009602843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003357181,0.00000462768,0.00004460154,0.0006849985,0.0000118214,0.00001740028,0.000009925285,0.00001052521,0.00004131066,0.000083572,0.9936213,0.005436246],"study_design_scores_gemma":[0.000207704,0.00006399627,0.0008806418,0.002634841,0.00007517017,0.0001777942,0.00006562802,0.00009081169,0.0001738672,0.0008990873,0.9946833,0.00004712255],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"commentary","genre_scores_codex":[0.0001852732,0.01698919,0.0007123511,0.3123512,0.658021,0.0007903939,0.00224517,0.0005454656,0.008160045],"genre_scores_gemma":[0.003940098,0.0204515,0.001382753,0.4352634,0.4749845,0.002975939,0.002467926,0.0007330422,0.05780086],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.09687333,"threshold_uncertainty_score":0.3240736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03287279875674169,"score_gpt":0.3085150873041266,"score_spread":0.2756422885473849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}