{"id":"W4403139892","doi":"10.1016/j.nmd.2024.07.127","title":"390P Assessing biomarkers of bone metabolism and the role of the IL-6 signalling pathway in patients with Duchenne muscular dystrophy","year":2024,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"Duchenne muscular dystrophy; Muscular dystrophy; Medicine; Bone remodeling; Signalling pathways; Metabolism; Signalling; Internal medicine; Endocrinology; Bioinformatics; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545249,0.0001922141,0.0002587169,0.00007151507,0.00007797848,0.00002296809,0.0001983369,0.0001040892,0.000004483234],"category_scores_gemma":[0.00008310228,0.0001120723,0.000199273,0.0002850291,0.0005511199,0.00001480281,0.0001267372,0.0001616213,3.001636e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003519943,"about_ca_system_score_gemma":0.00006519924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009659978,"about_ca_topic_score_gemma":0.00004204279,"domain_scores_codex":[0.9986684,0.0002738119,0.0002765219,0.0003699777,0.0001992268,0.0002120071],"domain_scores_gemma":[0.9993846,0.00004638709,0.0001127055,0.0003748531,0.00004941127,0.0000320134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001660254,0.00054958,0.04941288,0.0004587236,0.0009753227,0.000003394033,0.000779468,0.002351627,0.9078507,0.003140744,0.00002676792,0.03279056],"study_design_scores_gemma":[0.01109962,0.0006314298,0.8876589,0.0003267368,0.0004343812,0.000004423634,0.001440253,0.001928267,0.07806553,0.005882331,0.01169577,0.0008323692],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925033,0.006520213,0.0001357465,0.0001472848,0.0001008581,0.0003778926,0.00001732791,0.000007671145,0.0001897028],"genre_scores_gemma":[0.9995528,0.0002210169,0.00006578652,0.00006322579,0.00001711718,0.00002266213,0.00002426816,0.00002905116,0.000004071163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.838246,"threshold_uncertainty_score":0.4570176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001988680456223144,"score_gpt":0.1775824230437684,"score_spread":0.1755937425875453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}