{"id":"W4403144434","doi":"10.1016/j.matchemphys.2024.130007","title":"Reaction-assisted MOF manipulation for synthesis of UIO-66-NHCHO topology for prodrug fabrication: pH-responsive targeted drug delivery","year":2024,"lang":"en","type":"article","venue":"Materials Chemistry and Physics","topic":"Metal-Organic Frameworks: Synthesis and Applications","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Western University","keywords":"Prodrug; Drug delivery; Fabrication; Nanotechnology; Drug; Targeted drug delivery; Combinatorial chemistry; Materials science; Chemistry; Topology (electrical circuits); Pharmacology; Medicine; Engineering; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002162333,0.0002122821,0.0003752749,0.00001133219,0.0001478607,0.00007431152,0.000142417,0.000196989,0.0004170358],"category_scores_gemma":[0.0002478905,0.000210003,0.0001196401,0.0001085444,0.0000831347,0.0001044623,0.00003658941,0.00007747104,0.000004616414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004810452,"about_ca_system_score_gemma":0.00006881267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002395015,"about_ca_topic_score_gemma":7.863603e-7,"domain_scores_codex":[0.9987857,0.00002177666,0.0004557738,0.0004255062,0.0001058721,0.000205315],"domain_scores_gemma":[0.9983401,0.0008091035,0.0002440518,0.0003540792,0.0001952823,0.00005733247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001374563,0.00008672541,0.000006223723,0.002119861,0.0001209561,2.937597e-7,0.0001390866,0.000004503629,0.9821327,0.001319072,0.000859824,0.01307333],"study_design_scores_gemma":[0.0001607974,0.00000542273,0.00006159749,0.0002139181,0.0002174553,0.000004626054,0.0001804552,0.0006580156,0.9868699,0.00659302,0.004824908,0.0002098816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918177,0.0004316767,0.004602681,0.0007026585,0.0002043148,0.0004086792,0.001170627,0.0001232339,0.0005384501],"genre_scores_gemma":[0.9941002,0.00008842989,0.002417074,0.00001950326,0.0007739847,0.0008243551,0.0004601389,0.00004421181,0.001272118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01286345,"threshold_uncertainty_score":0.8563673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01743665254367039,"score_gpt":0.2540593824843789,"score_spread":0.2366227299407085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}