{"id":"W4403153642","doi":"10.1210/jendso/bvae163.285","title":"12484 Safety And Pharmacokinetics Of Anti-ACTH Antibody Lu AG13909 In Patients With Classic Congenital Adrenal Hyperplasia: Phase 1 Open-label, Multiple-Ascending-Dose Trial Protocol","year":2024,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Adrenal Hormones and Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Open label; Medicine; Congenital adrenal hyperplasia; Pharmacokinetics; Protocol (science); Antibody; Pediatrics; Urology; Internal medicine; Clinical trial; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001823806,0.00170366,0.00254316,0.0004258403,0.0006282119,0.001169456,0.0008278101,0.002040512,0.01801558],"category_scores_gemma":[0.001755808,0.0006413507,0.001368758,0.0004400226,0.000774572,0.001173047,0.0003757082,0.002856162,0.0028888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001017479,"about_ca_system_score_gemma":0.002323959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005572219,"about_ca_topic_score_gemma":0.001206764,"domain_scores_codex":[0.999234,0.0003377396,0.00006773661,0.0001509919,0.00008786827,0.0001216018],"domain_scores_gemma":[0.9992474,0.0001912505,0.0001588,0.00007945479,0.00009170622,0.0002314279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9038236,0.02096522,0.001569858,0.0018861,0.0009957767,0.0001267239,0.0001353112,0.001167013,0.005512039,0.0005371146,0.008606793,0.05467439],"study_design_scores_gemma":[0.8685593,0.117867,0.004942637,0.0001463543,0.0003304368,0.0001247405,0.0000309113,0.001148614,0.0006810991,0.0005708971,0.005560727,0.00003734237],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.7756636,0.01057712,0.004967352,0.002028991,0.001198134,0.1673074,0.01516669,0.0007198334,0.02237094],"genre_scores_gemma":[0.7914633,0.003314453,0.006336736,0.002568821,0.0004525577,0.1780477,0.005299725,0.0000857259,0.01243105],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01801558,"threshold_uncertainty_score":0.06026816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02322878210527711,"score_gpt":0.3643914957764502,"score_spread":0.3411627136711731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}