{"id":"W4403171978","doi":"10.1021/jacsau.4c00674","title":"Pyrimidine Azepine Targets the <i>Plasmodium bc</i><sub>1</sub> Complex and Displays Multistage Antimalarial Activity","year":2024,"lang":"en","type":"article","venue":"JACS Au","topic":"Malaria Research and Control","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"NHLBI Division of Intramural Research; National Center for Advancing Translational Sciences; Uniformed Services University of the Health Sciences; National Institutes of Health; Instituto Serrapilheira; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institute of Allergy and Infectious Diseases; Fundação de Amparo à Pesquisa do Estado de Goiás; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Plasmodium falciparum; Biology; Plasmodium berghei; Gametocyte; Malaria; Plasmodium (life cycle); Azepine; Parasite hosting; Pyrimidine; In vitro; Virology; Genetics; Chemistry; Stereochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005451517,0.0002311642,0.0003661427,0.00009667735,0.0002332677,0.0001514325,0.0001379161,0.0001153914,0.000223413],"category_scores_gemma":[0.0002663313,0.0001487728,0.0001256526,0.00021107,0.0002098295,0.0001422419,0.0001595344,0.0005611988,0.0001130816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009166999,"about_ca_system_score_gemma":0.000235695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003838839,"about_ca_topic_score_gemma":0.0001659678,"domain_scores_codex":[0.9982489,0.0001064318,0.0002071342,0.0004258234,0.0004542392,0.0005574835],"domain_scores_gemma":[0.9989151,0.000301929,0.00004074784,0.0003842962,0.00007119295,0.0002867554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001408231,0.0002178873,0.0008443633,0.0004171388,0.0002568089,0.0005272141,0.0002503962,0.000007207863,0.942957,0.00439416,0.01644867,0.03227091],"study_design_scores_gemma":[0.009426909,0.001238158,0.4886606,0.0003331573,0.0004906346,0.0003393544,0.00009273184,0.1744149,0.1964474,0.0004198954,0.1274472,0.0006891379],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9490326,0.0008812374,0.002844684,0.03946892,0.0006255381,0.001235578,0.0002121835,0.0001899805,0.005509246],"genre_scores_gemma":[0.9977072,0.0001772344,0.0001247227,0.0003603561,0.0009028561,0.0000577743,0.00006525532,0.00003785565,0.0005667422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7465096,"threshold_uncertainty_score":0.6066779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02180839730408785,"score_gpt":0.2853520880431968,"score_spread":0.2635436907391089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}