{"id":"W4403171978","doi":"10.1021/jacsau.4c00674","title":"Pyrimidine Azepine Targets the <i>Plasmodium bc</i><sub>1</sub> Complex and Displays Multistage Antimalarial Activity","year":2024,"lang":"en","type":"article","venue":"JACS Au","topic":"Malaria Research and Control","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"NHLBI Division of Intramural Research; National Center for Advancing Translational Sciences; Uniformed Services University of the Health Sciences; National Institutes of Health; Instituto Serrapilheira; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institute of Allergy and Infectious Diseases; Fundação de Amparo à Pesquisa do Estado de Goiás; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Plasmodium falciparum; Biology; Plasmodium berghei; Gametocyte; Malaria; Plasmodium (life cycle); Azepine; Parasite hosting; Pyrimidine; In vitro; Virology; Genetics; Chemistry; Stereochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007212354,0.0003203037,0.000245148,0.000177289,0.0001356343,0.0002012086,0.0001728551,0.0001501483,0.001806181],"category_scores_gemma":[0.00008812374,0.00009200688,0.0001006393,0.0001738366,0.0001350137,0.0001666914,0.0001029356,0.0003169052,0.0004365332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528751,"about_ca_system_score_gemma":0.0001592336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008682408,"about_ca_topic_score_gemma":0.001888974,"domain_scores_codex":[0.9999309,0.00001079899,0.000004458482,0.00001476961,0.00002782125,0.00001136375],"domain_scores_gemma":[0.9999437,0.00001083198,0.00001792865,0.000004693464,0.00001177402,0.00001102395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005214593,0.0000098235,0.0001369393,0.00002288033,0.000002146236,0.00001895506,0.00000305103,0.00005465832,0.9975389,0.00003720172,0.00006830088,0.002054851],"study_design_scores_gemma":[0.00001247256,0.0003307666,0.003467692,0.000001942884,0.000006015025,0.0002331837,0.000006529609,0.0004760489,0.9933728,0.00002608595,0.002063503,0.000002911107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718484,0.002870955,0.01506704,0.0003176043,0.00004070506,0.0001588186,0.001914323,0.0003915783,0.007390576],"genre_scores_gemma":[0.9773467,0.002501096,0.01361514,0.00009960357,0.00001613919,0.00005064902,0.001638376,0.00003535518,0.004696781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001806181,"threshold_uncertainty_score":0.006042242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02180839730408785,"score_gpt":0.2853520880431968,"score_spread":0.2635436907391089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}