{"id":"W4403173108","doi":"10.1038/s41397-024-00352-z","title":"Effects and interaction of single nucleotide polymorphisms at the pharmacokinetic/pharmacodynamic site: insights from the Rotterdam study into metformin clinical response and dose titration","year":2024,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Pharmacodynamics; Metformin; Pharmacokinetics; Single-nucleotide polymorphism; Pharmacology; Medicine; Rotterdam Study; Internal medicine; Genetics; Biology; Genotype; Confidence interval; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001394048,0.0002100287,0.0002626107,0.00009970523,0.0003287215,0.0001559829,0.0001610096,0.00003054167,0.00007643936],"category_scores_gemma":[0.00004078666,0.0001000624,0.000128338,0.0001425926,0.0001923325,0.0001923695,0.0002272947,0.0004547108,0.00002559304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001714815,"about_ca_system_score_gemma":0.00004132502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004982294,"about_ca_topic_score_gemma":0.00002665372,"domain_scores_codex":[0.998112,0.00071846,0.0005080011,0.0002411435,0.0002478257,0.0001725648],"domain_scores_gemma":[0.9978675,0.001587224,0.0001981639,0.0001821955,0.00004394138,0.0001210334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00562086,0.0005721937,0.002753784,0.00004363456,0.001989238,0.0002122143,0.006582633,0.00002743878,0.8533529,0.00000954439,0.001770817,0.1270647],"study_design_scores_gemma":[0.05052093,0.009292587,0.3178339,0.001126369,0.04183223,0.001882332,0.006114909,0.08531526,0.3560826,0.002288584,0.1263463,0.001363985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822538,0.01088129,0.00005043572,0.004469866,0.00104481,0.00119597,0.00001002474,0.00002521554,0.00006860491],"genre_scores_gemma":[0.9952267,0.002757729,0.00005142971,0.001030706,0.0006221474,0.00002493478,0.000008948581,0.00003247594,0.000244897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4972703,"threshold_uncertainty_score":0.4080425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02468025439430307,"score_gpt":0.3387059396730713,"score_spread":0.3140256852787682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}