{"id":"W4403185136","doi":"10.1016/j.cub.2024.08.029","title":"Aminoacyl-tRNA synthetases","year":2024,"lang":"en","type":"review","venue":"Current Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Transfer RNA; Aminoacyl tRNA synthetase; Computational biology; Evolutionary biology; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002379457,0.0005878849,0.001088393,0.0001503979,0.00006128323,0.00003781796,0.0005740395,0.0007009324,0.0001055357],"category_scores_gemma":[0.00013226,0.0004112483,0.0007964437,0.0001329067,0.0001286078,0.00000133292,0.0003695159,0.0003041026,0.001063516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002274759,"about_ca_system_score_gemma":0.0002223243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002443664,"about_ca_topic_score_gemma":0.000001955246,"domain_scores_codex":[0.9977548,0.0003198457,0.0005094619,0.0009092491,0.00007435223,0.00043225],"domain_scores_gemma":[0.9988981,0.00004377208,0.0002081808,0.0007040366,0.0000334675,0.0001124038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003579561,0.00003459645,4.272956e-7,0.004557478,0.000199275,0.000004060788,0.00000216084,1.556085e-8,0.0006906192,0.001067983,0.006388307,0.9870515],"study_design_scores_gemma":[0.00004287718,0.0001356722,4.564281e-8,0.002923968,0.0007343287,0.00006344409,0.000001719686,2.457716e-7,0.000771357,0.0003712738,0.9944895,0.0004655837],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000005669956,0.9944563,0.0003321804,0.00001207295,0.003322379,0.000523428,0.0004071551,0.00004724831,0.0008935467],"genre_scores_gemma":[0.00002629303,0.9955934,0.00009513898,0.00003083233,0.00155655,0.0003065506,0.001658364,0.00008658597,0.0006463334],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9881012,"threshold_uncertainty_score":0.9998339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07679031049334571,"score_gpt":0.3893287592254046,"score_spread":0.3125384487320588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}