{"id":"W4403189001","doi":"10.1128/mbio.01827-24","title":"CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies","year":2024,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; International AIDS Vaccine Initiative; National Institutes of Health; Tulane University; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Virology; Antibody; Biology; Neutralizing antibody; Epitope; Glycoprotein; Flow cytometry; Antigen; Messenger RNA; Molecular biology; Virus; Immunology; Monoclonal antibody; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353458,0.0002938129,0.0003052634,0.0001792239,0.0001629962,0.0003414631,0.0002616644,0.0003456436,0.002851708],"category_scores_gemma":[0.0001974385,0.0001551576,0.0001757754,0.0001139384,0.0002621233,0.000290866,0.0001771847,0.0008836443,0.0005404611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005072847,"about_ca_system_score_gemma":0.000219249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006110339,"about_ca_topic_score_gemma":0.0005878796,"domain_scores_codex":[0.9997925,0.00003296739,0.00001430547,0.00003672696,0.00004999569,0.00007354029],"domain_scores_gemma":[0.9998765,0.00003896143,0.00001807444,0.00002258855,0.00002328895,0.00002062252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001580576,0.00003490914,0.0001691297,0.00002324474,0.000002507451,0.00002269589,0.00001043828,0.00004131729,0.9985726,0.00007839977,0.00002406472,0.0008625987],"study_design_scores_gemma":[0.00001845806,0.0003032276,0.00507014,0.000005178299,0.000008386799,0.0001011029,0.00002159475,0.0009365851,0.9924412,0.00005961672,0.001032177,0.000002340667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941834,0.001217753,0.002199437,0.00008374121,0.0000347494,0.0000365966,0.0002540557,0.0000905246,0.001899846],"genre_scores_gemma":[0.9959111,0.0002870165,0.0008950501,0.00005422032,0.00001277353,0.0000388836,0.000258377,0.00001370983,0.002528917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002851708,"threshold_uncertainty_score":0.009539843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008799859592567998,"score_gpt":0.2430949260000956,"score_spread":0.2342950664075276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}