{"id":"W4403198627","doi":"10.1111/all.16318","title":"The epithelial barrier theory and its associated diseases","year":2024,"lang":"en","type":"review","venue":"Allergy","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Science Foundation; LEO Fondet; European Academy of Allergy and Clinical Immunology; Promedica Stiftung; Biotechnology and Biological Sciences Research Council; Asthma and Lung UK; National Institute for Health and Care Research; National Institutes of Health; Rosetrees Trust; Regeneron Pharmaceuticals; LEO Pharma; Immune Tolerance Network; European Commission; Sanofi; Incyte; Pfizer; Novartis Pharmaceuticals Corporation; Allergy Therapeutics; AstraZeneca; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Food Allergy Research and Education; Amgen","keywords":"Dysbiosis; Inflammation; Immunology; Immune system; Commensalism; Colonization; Biology; Medicine; Microbiology; Gut flora; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115488,0.0003066968,0.0004804383,0.00006050276,0.0002729798,0.0001863057,0.0004326836,0.0001560332,0.0001084652],"category_scores_gemma":[0.002181826,0.0001655173,0.0003012532,0.0002473725,0.0001572607,0.00005013532,0.0002129219,0.0002871733,0.0003192654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002735419,"about_ca_system_score_gemma":0.0001527113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001290763,"about_ca_topic_score_gemma":0.00001011308,"domain_scores_codex":[0.9980537,0.0006826125,0.0002491094,0.0004824317,0.0002180936,0.0003140071],"domain_scores_gemma":[0.9977046,0.001820422,0.0001073354,0.0002440301,0.0000117331,0.0001119384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001155973,0.00003529318,2.81264e-8,0.001072526,0.0001787574,0.00005769066,0.00006248282,7.56453e-8,0.00002025244,0.09883873,0.007880102,0.8918425],"study_design_scores_gemma":[0.00007503273,0.00001736849,0.000001578342,0.0009276291,0.0001280023,0.000007966563,0.00000941003,0.000003971654,0.00001179985,0.004910142,0.9936979,0.0002091855],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001804045,0.9963486,4.564733e-7,0.000077445,0.0007190745,0.0002811067,0.0003329339,0.0001221095,0.00210029],"genre_scores_gemma":[0.0001650236,0.987312,2.118116e-7,0.00030009,0.0001431513,0.00007453221,0.00001369533,0.00005856357,0.0119328],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9858178,"threshold_uncertainty_score":0.6749599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03178870411822256,"score_gpt":0.3064063275907375,"score_spread":0.274617623472515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}