{"id":"W4403198657","doi":"10.1111/all.16351","title":"Long‐term safety and efficacy of garadacimab for preventing hereditary angioedema attacks: Phase 3 open‐label extension study","year":2024,"lang":"en","type":"article","venue":"Allergy","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"CSL Behring","keywords":"Hereditary angioedema; Medicine; Open label; Term (time); Dermatology; Angioedema; Intensive care medicine; Pediatrics; Adverse effect; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004325896,0.0002332785,0.0005246368,0.0001218681,0.0001398092,0.00006041799,0.0001498454,0.00008757061,0.0001267511],"category_scores_gemma":[0.0001180133,0.0002024983,0.000127891,0.00020477,0.00006569357,0.0002382918,0.0001416531,0.00009209556,0.000005479206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003393009,"about_ca_system_score_gemma":0.0001078593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000841587,"about_ca_topic_score_gemma":0.00006979786,"domain_scores_codex":[0.9983025,0.00004842265,0.0005751576,0.0005366851,0.0002441546,0.0002931338],"domain_scores_gemma":[0.9989381,0.0003226662,0.000111806,0.0003727483,0.0001121462,0.0001424889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01334548,0.01858282,0.03345893,0.002791133,0.00542168,0.001355756,0.01104654,0.00006975139,0.01503379,0.001933896,0.02606612,0.8708941],"study_design_scores_gemma":[0.08819668,0.01249024,0.830335,0.004481053,0.001869928,0.0005937313,0.001364252,0.01782166,0.004601678,0.0004181685,0.03654911,0.001278485],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777589,0.01793936,0.000894602,0.0005678365,0.0004701817,0.001886314,0.00003958871,0.0001057256,0.0003374486],"genre_scores_gemma":[0.9960495,0.0002233167,0.0006910377,0.0001233614,0.0003714007,0.00003899512,0.0001774094,0.00005809537,0.002266837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8696156,"threshold_uncertainty_score":0.8257639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05614138852836718,"score_gpt":0.3756194913572406,"score_spread":0.3194781028288734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}