{"id":"W4403198657","doi":"10.1111/all.16351","title":"Long‐term safety and efficacy of garadacimab for preventing hereditary angioedema attacks: Phase 3 open‐label extension study","year":2024,"lang":"en","type":"article","venue":"Allergy","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"CSL Behring","keywords":"Hereditary angioedema; Medicine; Open label; Term (time); Dermatology; Angioedema; Intensive care medicine; Pediatrics; Adverse effect; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003533015,0.001050957,0.001458364,0.0002688212,0.00036391,0.001045828,0.0006756149,0.0009286968,0.004287304],"category_scores_gemma":[0.001411951,0.0003695503,0.001374973,0.000296755,0.0006640577,0.0007719469,0.0003893666,0.002693115,0.0008420728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007067844,"about_ca_system_score_gemma":0.001814815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000604908,"about_ca_topic_score_gemma":0.001214362,"domain_scores_codex":[0.9992855,0.0003182292,0.00003470007,0.00009916411,0.0001053688,0.0001570333],"domain_scores_gemma":[0.9986187,0.0002457976,0.0003944749,0.0001535377,0.0001299561,0.0004573721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7815494,0.04723247,0.01348356,0.001078986,0.002002744,0.0003268836,0.0004334423,0.002410711,0.04429721,0.0004624714,0.007438073,0.09928404],"study_design_scores_gemma":[0.5491773,0.3940092,0.03844801,0.0001233866,0.0009152596,0.000704255,0.0001081462,0.002086212,0.006954742,0.0004810562,0.006932291,0.00006012242],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917762,0.001523143,0.0008703683,0.0002852562,0.00007245436,0.001910768,0.001896688,0.0001215381,0.001543589],"genre_scores_gemma":[0.9876384,0.0009717556,0.002083496,0.0008709279,0.00009219682,0.002476088,0.003593899,0.00004494797,0.002228244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004287304,"threshold_uncertainty_score":0.01868463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05614138852836718,"score_gpt":0.3756194913572406,"score_spread":0.3194781028288734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}