{"id":"W4403202565","doi":"10.1002/cbic.202400493","title":"Ligand‐Induced Folding in a Dopamine‐Binding DNA Aptamer","year":2024,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Isothermal titration calorimetry; Chemistry; Biosensor; Circular dichroism; Systematic evolution of ligands by exponential enrichment; Ligand (biochemistry); DNA; Biophysics; Nuclear magnetic resonance spectroscopy; Molecular recognition; Stereochemistry; Molecule; Biochemistry; RNA; Biology; Receptor; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002118462,0.0002113228,0.0001872975,0.0001407006,0.00004552388,0.00006512623,0.0001534547,0.0002159309,0.000003058966],"category_scores_gemma":[0.00007436745,0.0001933871,0.0001477891,0.0003649125,0.00004893922,0.000006537709,0.0001080866,0.0001601576,0.00001557669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004481371,"about_ca_system_score_gemma":0.00004653019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007881472,"about_ca_topic_score_gemma":0.00001328562,"domain_scores_codex":[0.9987644,0.00001783165,0.0002358144,0.0005468943,0.0001198162,0.0003152433],"domain_scores_gemma":[0.9995374,0.00001354779,0.00003962055,0.0003087156,0.00003485101,0.00006588197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001398846,0.00002738916,0.0001626612,0.00003280409,0.00004307557,0.00002547365,0.0000260613,3.623454e-7,0.9926344,0.00004861849,0.0006081947,0.006376975],"study_design_scores_gemma":[0.0001490943,0.00006309663,0.00005718151,0.0001211269,0.0000236144,0.00002592141,0.00008557634,0.0001091982,0.9919855,0.00006195531,0.007049978,0.0002677514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960709,0.0009668114,0.0002293625,0.0001836412,0.000121246,0.00010572,0.000006109188,0.0001164511,0.002199817],"genre_scores_gemma":[0.9971846,0.0001651126,0.001003915,0.000101893,0.0002914558,0.00001552602,0.00008814667,0.0000369806,0.001112371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006441783,"threshold_uncertainty_score":0.7886096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385281186049829,"score_gpt":0.2845363917159434,"score_spread":0.2706835798554451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}