{"id":"W4403202565","doi":"10.1002/cbic.202400493","title":"Ligand‐Induced Folding in a Dopamine‐Binding DNA Aptamer","year":2024,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Isothermal titration calorimetry; Chemistry; Biosensor; Circular dichroism; Systematic evolution of ligands by exponential enrichment; Ligand (biochemistry); DNA; Biophysics; Nuclear magnetic resonance spectroscopy; Molecular recognition; Stereochemistry; Molecule; Biochemistry; RNA; Biology; Receptor; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001630753,0.0002588212,0.0002692396,0.0001516976,0.0001079856,0.0001828935,0.0001822191,0.0003263679,0.0004218499],"category_scores_gemma":[0.0003972671,0.0001462937,0.0002386227,0.0001100682,0.0002014558,0.0001282428,0.0001066631,0.0004111359,0.000176729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798308,"about_ca_system_score_gemma":0.0001592033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003575122,"about_ca_topic_score_gemma":0.0004319369,"domain_scores_codex":[0.9998537,0.00003179351,0.00001059089,0.00003823628,0.00004254515,0.00002311327],"domain_scores_gemma":[0.9997386,0.00008112962,0.00006671708,0.00001802254,0.00004473145,0.00005074972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003805075,0.00001268757,0.0001592774,0.00001273107,0.00000421233,0.00002517864,0.00001372903,0.0002973608,0.9989995,0.0000319173,0.000006681374,0.0003985892],"study_design_scores_gemma":[0.000006336847,0.0002014554,0.001260818,0.000002349265,0.000005641249,0.0000797399,0.000008026385,0.002658391,0.99542,0.00002958643,0.0003230498,0.000004704127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949852,0.0001929489,0.004421743,0.00002966545,0.00001482784,0.0000190151,0.00008276468,0.00003361954,0.0002200874],"genre_scores_gemma":[0.9941674,0.00006670654,0.004916611,0.00003635075,0.000003630556,0.00001787038,0.0001386164,0.00001355213,0.0006391171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004218499,"threshold_uncertainty_score":0.002030313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385281186049829,"score_gpt":0.2845363917159434,"score_spread":0.2706835798554451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}