{"id":"W4403205323","doi":"10.1007/s11357-024-01368-w","title":"Hyperactive mTORC1/4EBP1 signaling dysregulates proteostasis and accelerates cardiac aging","year":2024,"lang":"en","type":"article","venue":"GeroScience","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; McGill University; American Heart Association","keywords":"Proteostasis; mTORC1; Cell biology; Chemistry; Signal transduction; PI3K/AKT/mTOR pathway; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002765924,0.0005659112,0.0005661932,0.0006806416,0.0002796926,0.0005586527,0.0002871493,0.0005010059,0.003106819],"category_scores_gemma":[0.0001777924,0.0002695357,0.0004247783,0.0002866594,0.0006183072,0.0002994756,0.0004740556,0.0009389987,0.0004084452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005358725,"about_ca_system_score_gemma":0.0003847389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007227454,"about_ca_topic_score_gemma":0.001466948,"domain_scores_codex":[0.9997533,0.00003667914,0.00001858303,0.00006214325,0.00005478519,0.00007448022],"domain_scores_gemma":[0.9998326,0.00001313863,0.00006182471,0.00001889305,0.00001176031,0.00006168701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001713215,0.000111198,0.0008913277,0.0001065069,0.00005799037,0.000168531,0.00002690029,0.0001904484,0.9911779,0.0005882244,0.0005486927,0.004419147],"study_design_scores_gemma":[0.0002875008,0.001488853,0.05355443,0.00004415443,0.0002616192,0.0008040897,0.0002621907,0.00269809,0.9286754,0.001134608,0.01074309,0.00004596184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863243,0.005890753,0.003102591,0.0006947573,0.0003577901,0.00003014281,0.001107556,0.0004681399,0.002023996],"genre_scores_gemma":[0.9926554,0.002034963,0.001025578,0.0002380434,0.00004773971,0.0000481157,0.0005194276,0.00006869603,0.003362094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003106819,"threshold_uncertainty_score":0.01039338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01244132920115006,"score_gpt":0.2529053771684633,"score_spread":0.2404640479673133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}