{"id":"W4403208447","doi":"10.1021/acsfoodscitech.4c00399","title":"Kurarinone, a Lavandulyl Flavanone from <i>Sophora flavescens</i>, Inhibits T-type Calcium Channels and Exerts Analgesic Effects in a Mouse Model of Inflammatory Pain","year":2024,"lang":"en","type":"article","venue":"ACS Food Science & Technology","topic":"Bioactive natural compounds","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Mitacs; Canada Research Chairs; Hotchkiss Brain Institute, University of Calgary; University of Calgary","keywords":"Sophora flavescens; Flavanone; Analgesic; Pharmacology; Medicine; Calcium; Chemistry; Internal medicine; Biochemistry; Flavonoid; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005902906,0.0002471872,0.0002908825,0.0007701511,0.00008058299,0.0000462261,0.0005021206,0.0004785512,7.169284e-7],"category_scores_gemma":[0.0002832164,0.0002299462,0.00004234081,0.001379011,0.001078232,0.00003328523,0.0005439369,0.0003829359,0.000002428175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005896255,"about_ca_system_score_gemma":0.00029609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002775041,"about_ca_topic_score_gemma":0.0001067124,"domain_scores_codex":[0.9981171,0.00006166477,0.0002811378,0.0008055127,0.0002380712,0.0004965134],"domain_scores_gemma":[0.999172,0.0000475662,0.0000782237,0.0004659088,0.000140238,0.00009610899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005385895,0.0000387354,0.000986813,0.00005335968,0.00002508118,0.00001076111,0.00010788,0.00007280822,0.9950747,0.0005839464,0.00006205289,0.002929955],"study_design_scores_gemma":[0.0003477751,0.0007585567,0.0002198385,0.00008865438,0.00001255941,0.00001085445,0.00006020123,0.003824777,0.9912323,0.003033101,0.0001654162,0.0002459351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929758,0.005180421,0.0009149453,0.0002978108,0.0001669868,0.0003099905,0.00002364647,0.0000806831,0.0000497305],"genre_scores_gemma":[0.9987892,0.0001708119,0.0007461412,0.0001240727,0.00004152602,0.00002002168,0.00001346206,0.00002410425,0.0000706862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005813389,"threshold_uncertainty_score":0.9376934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110665711562586,"score_gpt":0.2411848152252541,"score_spread":0.2300781581096282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}