{"id":"W4403208467","doi":"10.1186/s40035-024-00443-8","title":"Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice","year":2024,"lang":"en","type":"article","venue":"Translational Neurodegeneration","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Pacific Centre for Reproductive Medicine; University of British Columbia","funders":"Huntington's Disease Society of America","keywords":"Huntingtin; Huntington's disease; Neurology; Mutant; Disease; Neuroscience; Huntingtin Protein; Neurofilament; Molecular neuroscience; Medicine; Internal medicine; Chemistry; Endocrinology; Biology; Gene; Biochemistry; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005771547,0.0002571636,0.000212555,0.000393246,0.0001416168,0.0001948105,0.0002174203,0.0000429743,0.00002589057],"category_scores_gemma":[0.00116231,0.0002329688,0.00006905248,0.001059131,0.00008236586,0.0002803955,0.0000314051,0.0002179082,0.000007008259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003470942,"about_ca_system_score_gemma":0.0002024097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001225068,"about_ca_topic_score_gemma":0.0002241685,"domain_scores_codex":[0.9966685,0.0009915807,0.0006593505,0.0007898003,0.0005747453,0.0003160529],"domain_scores_gemma":[0.9983928,0.001061331,0.0000974027,0.0002599015,0.00006782904,0.0001207605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005738982,0.0001621741,0.005382334,0.00005658815,0.000001982566,0.00002847863,0.001940714,0.03101981,0.9584981,0.0021376,0.00001648691,0.000181866],"study_design_scores_gemma":[0.0007063036,0.00008739516,0.1645515,0.00009197563,0.0000167529,0.000003569796,0.00007774047,0.04055249,0.7932946,0.0001440854,0.0002696328,0.0002039603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838996,0.00006990346,0.0006166331,0.01377614,0.0002140203,0.001164117,0.0001619844,0.00005773605,0.00003990007],"genre_scores_gemma":[0.99848,0.00002655663,0.0001252199,0.00107235,0.00005968349,0.0001453572,0.00002462258,0.00003618295,0.00003008643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1652034,"threshold_uncertainty_score":0.9500191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02320123427860886,"score_gpt":0.2682429405763509,"score_spread":0.245041706297742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}