{"id":"W4403208474","doi":"10.1186/s40246-024-00679-5","title":"Leveraging large-scale datasets and single cell omics data to develop a polygenic score for cisplatin-induced ototoxicity","year":2024,"lang":"en","type":"article","venue":"Human Genomics","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; Sunnybrook Hospital; CancerCare Manitoba; Research Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba; Research Manitoba; CancerCare Manitoba Foundation; Health Sciences Centre Research Foundation","keywords":"Genome-wide association study; Biology; Ototoxicity; Cohort; Human genetics; Single-nucleotide polymorphism; Hearing loss; Computational biology; Genetic association; Cisplatin; Oncology; Bioinformatics; Genetics; Medicine; Internal medicine; Gene; Genotype; Audiology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006362228,0.0003195112,0.0002881154,0.0002091002,0.0005224471,0.0005447335,0.001027122,0.0001297857,0.00002711334],"category_scores_gemma":[0.0004005146,0.0003694527,0.0000357412,0.0004229349,0.00006482343,0.0002378374,0.001796118,0.0003105179,0.0001116153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000197345,"about_ca_system_score_gemma":0.0003366674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002472238,"about_ca_topic_score_gemma":0.0001845515,"domain_scores_codex":[0.9971052,0.00006785419,0.0004871033,0.001342668,0.000239495,0.0007576505],"domain_scores_gemma":[0.997977,0.0002429529,0.00009088692,0.001341068,0.00005369059,0.000294402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002117498,0.00007438818,0.0001490693,0.0001584688,0.000007220846,0.00002098909,0.002140941,0.00005347117,0.9924458,0.0001707682,0.003309665,0.001448031],"study_design_scores_gemma":[0.0009586777,0.0002596572,0.00165681,0.0001012254,0.00007996325,0.00006668078,0.0003613082,0.03262557,0.7987818,0.0004768537,0.1636082,0.001023317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874824,0.0001444376,0.00721738,0.0001230467,0.0004035329,0.0009882513,0.003231501,0.0001625945,0.0002468468],"genre_scores_gemma":[0.9823693,0.00002671249,0.01492681,0.001235967,0.0002866175,0.00002777043,0.0007129489,0.0001293921,0.0002845089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1936641,"threshold_uncertainty_score":0.9998757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1830574980394769,"score_gpt":0.3332120689475547,"score_spread":0.1501545709080778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}