{"id":"W4403209110","doi":"10.1038/s41467-024-52801-9","title":"Transcriptional coactivator MED15 is required for beta cell maturation","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Center for Research Resources; Regeneron Pharmaceuticals; Diabetes Canada; Natural Sciences and Engineering Research Council of Canada; University of California, Davis; National Institutes of Health; Government of Canada; National Human Genome Research Institute; Michael Smith Health Research BC; BC Children's Hospital; Canadian Institutes of Health Research; Juvenile Diabetes Research Foundation United States of America","keywords":"BETA (programming language); Coactivator; Cell biology; Biology; Computational biology; Computer science; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001812134,0.0002916246,0.0002528404,0.0001861223,0.0002177208,0.0005665888,0.0002879048,0.0003864558,0.002332112],"category_scores_gemma":[0.0002737279,0.00026192,0.000318499,0.0001223331,0.0003145852,0.0002725509,0.0006707796,0.0006230625,0.001171847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003166252,"about_ca_system_score_gemma":0.0002190211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002658488,"about_ca_topic_score_gemma":0.0004050508,"domain_scores_codex":[0.9998115,0.00001499016,0.00001989112,0.00007000954,0.00004800927,0.0000356461],"domain_scores_gemma":[0.9997296,0.00004060166,0.00008867244,0.00003638246,0.00002354721,0.00008118593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002048933,0.000007590223,0.001051508,0.00003687129,0.000006087712,0.0001482609,0.000022178,0.00004567923,0.995487,0.0002595027,0.0001123184,0.002618049],"study_design_scores_gemma":[0.00002752312,0.00009717953,0.02007647,0.00001843843,0.00002014946,0.0008505762,0.00004549842,0.0007987441,0.9680954,0.0002053576,0.009756718,0.000007916911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782442,0.00421543,0.01116664,0.0004049996,0.0002019153,0.00002479217,0.001026314,0.0004773447,0.004238457],"genre_scores_gemma":[0.9913281,0.0007579945,0.002787274,0.0001693293,0.00002350412,0.00001410303,0.001111455,0.0001080395,0.003700191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002332112,"threshold_uncertainty_score":0.007801712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03796139106583332,"score_gpt":0.3269139281587431,"score_spread":0.2889525370929098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}