{"id":"W4403209182","doi":"10.1038/s41433-024-03370-0","title":"Treatment regimens for optimising outcomes in patients with neovascular age-related macular degeneration","year":2024,"lang":"en","type":"review","venue":"Eye","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto; St. Joseph’s Healthcare Hamilton; St. Michael's Hospital","funders":"","keywords":"Macular degeneration; Medicine; Ranibizumab; Bevacizumab; Clinical trial; Disease; Intensive care medicine; Clinical Practice; Aflibercept; Ophthalmology; Internal medicine; Physical therapy; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008127797,0.0005249385,0.001128586,0.001646833,0.000228978,0.0007739179,0.0006690772,0.0008038408,0.004449302],"category_scores_gemma":[0.001819131,0.0001626191,0.001236784,0.0009603464,0.0002308881,0.0008176753,0.0004259219,0.001246767,0.0008695211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004353698,"about_ca_system_score_gemma":0.0007762878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009655021,"about_ca_topic_score_gemma":0.002782268,"domain_scores_codex":[0.9996051,0.0001156578,0.00009996278,0.00004741013,0.0001056879,0.00002613306],"domain_scores_gemma":[0.9995182,0.0003053474,0.00009016829,0.000009102324,0.00006409334,0.00001305351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001383129,0.00006708712,0.0001959159,0.04989043,0.0003134809,0.00007577488,0.00005502922,0.0001779728,0.0005419509,0.001409573,0.01139309,0.9357415],"study_design_scores_gemma":[0.0002887401,0.0005587585,0.004600738,0.0880744,0.002399942,0.002448254,0.0002029613,0.000297003,0.001054576,0.003024383,0.8970003,0.00005002838],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001879266,0.9988793,0.00006982197,0.0001878546,0.00008675986,0.00001142807,0.00002220486,0.000004175457,0.0005505321],"genre_scores_gemma":[0.00152072,0.9976287,0.0003138706,0.0002186373,0.00007536106,0.00001544614,0.00003844364,0.000001627201,0.0001871373],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004449302,"threshold_uncertainty_score":0.01488441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03063140432009519,"score_gpt":0.3468641558240158,"score_spread":0.3162327515039206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}