{"id":"W4403213288","doi":"10.3390/curroncol31100450","title":"Ritonavir’s Evolving Role: A Journey from Antiretroviral Therapy to Broader Medical Applications","year":2024,"lang":"en","type":"review","venue":"Current Oncology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Fundação para a Ciência e a Tecnologia","keywords":"Ritonavir; Medicine; Repurposing; Drug repositioning; Pharmacology; Gemcitabine; Ketoconazole; Cancer research; Cancer; Oncology; Drug; Internal medicine; Immunology; Biology; Human immunodeficiency virus (HIV); Viral load; Antiretroviral therapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001943395,0.0004670541,0.001057603,0.0009483054,0.0004197187,0.002271887,0.0006803692,0.001641237,0.002624277],"category_scores_gemma":[0.001621741,0.0002666354,0.0003818989,0.001052322,0.001458535,0.003930321,0.001250005,0.004424161,0.001238038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001101705,"about_ca_system_score_gemma":0.001948375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005919625,"about_ca_topic_score_gemma":0.0009509211,"domain_scores_codex":[0.999461,0.000179804,0.00007071871,0.00007075096,0.000151591,0.00006613439],"domain_scores_gemma":[0.9990533,0.0004301394,0.00008447465,0.00004445134,0.0002283251,0.0001593747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001495108,0.0000962201,0.0003448243,0.004245287,0.00005633103,0.0003373872,0.0006487419,0.0003850575,0.003500927,0.03750529,0.06011307,0.8926173],"study_design_scores_gemma":[0.00001041254,0.0001054525,0.0002311194,0.001018786,0.00001605801,0.0005528961,0.0002160879,0.0000905968,0.0003404334,0.008328899,0.9890757,0.0000135794],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003846714,0.9880001,0.0004734882,0.008354476,0.001032132,0.000003740779,0.00001125386,0.00002217176,0.001717941],"genre_scores_gemma":[0.003555116,0.9900873,0.0008904362,0.002641455,0.00147245,0.000008178406,0.00002266785,0.00001045481,0.001311913],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002624277,"threshold_uncertainty_score":0.01027775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08704382482109439,"score_gpt":0.4547717019148416,"score_spread":0.3677278770937472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}