{"id":"W4403219926","doi":"10.1182/bloodadvances.2024013845","title":"Adeno-associated virus and hepatocytes: frenemies?","year":2024,"lang":"en","type":"letter","venue":"Blood Advances","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Virology; Virus; Adeno-associated virus; Medicine; Biology; Genetics; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002555143,0.0005985373,0.0008724898,0.000400059,0.001335429,0.00312417,0.000884062,0.02828035,0.004922622],"category_scores_gemma":[0.007297943,0.0002864734,0.0005026648,0.0003086169,0.003521527,0.003878945,0.001051405,0.0176508,0.002605935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002277234,"about_ca_system_score_gemma":0.00116088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00137563,"about_ca_topic_score_gemma":0.002423868,"domain_scores_codex":[0.9988045,0.0004667066,0.0001098312,0.0001586548,0.0003147395,0.0001456776],"domain_scores_gemma":[0.9975533,0.001777767,0.0001530141,0.0001126141,0.000169826,0.0002335143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004958541,0.00009555409,0.0008428675,0.0002163895,0.00004362586,0.008295857,0.0001958454,0.0001299548,0.001459247,0.0428002,0.8830992,0.06232546],"study_design_scores_gemma":[0.0002948659,0.0001347365,0.0006844957,0.0001864805,0.00002643825,0.004573035,0.0003759816,0.0003644596,0.0007247484,0.06102142,0.9315714,0.00004191231],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.001268303,0.01469629,0.0004902364,0.9540069,0.02429765,0.00001310544,0.00003017247,0.00003231941,0.005165145],"genre_scores_gemma":[0.02922796,0.01854881,0.0008820941,0.7711602,0.1555597,0.00008154416,0.00003982089,0.00003636822,0.02446347],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.02828035,"threshold_uncertainty_score":0.01652259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319626864956692,"score_gpt":0.2827732101815407,"score_spread":0.2695769415319738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}