{"id":"W4403219926","doi":"10.1182/bloodadvances.2024013845","title":"Adeno-associated virus and hepatocytes: frenemies?","year":2024,"lang":"en","type":"letter","venue":"Blood Advances","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Virology; Virus; Adeno-associated virus; Medicine; Biology; Genetics; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001779185,0.0004264839,0.0003670935,0.0001092254,0.0001050793,0.0001086829,0.000402211,0.0008140863,0.00008175812],"category_scores_gemma":[0.00009871191,0.0003931001,0.0001535611,0.0001365059,0.0002015948,0.000006164663,0.0002407632,0.0008949476,0.00007723333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002139246,"about_ca_system_score_gemma":0.0001606922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002877603,"about_ca_topic_score_gemma":0.0003380468,"domain_scores_codex":[0.9978058,0.0001386657,0.0002700804,0.0008543241,0.0003668597,0.0005642558],"domain_scores_gemma":[0.9991497,0.00004592644,0.0001173128,0.000513519,0.00009038752,0.00008312554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002457066,0.00008781035,0.0003682461,0.0003976422,0.0009221042,0.0004316275,0.00004578028,0.000005802482,0.1383095,0.000002452829,0.8546413,0.004541993],"study_design_scores_gemma":[0.0004492865,0.001417869,0.00001403579,0.0001072245,0.0001177711,0.00002514289,0.00001008509,0.000004185313,0.1640044,0.0002485362,0.8331735,0.000427956],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.3636837,0.516036,0.00001443518,0.1134508,0.001114603,0.001069262,0.001511912,0.0002173422,0.002901975],"genre_scores_gemma":[0.04675134,0.1305224,0.0005901443,0.7328139,0.02005801,0.0008316722,0.007666581,0.0009179037,0.05984799],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.6193631,"threshold_uncertainty_score":0.9998521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319626864956692,"score_gpt":0.2827732101815407,"score_spread":0.2695769415319738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}