{"id":"W4403220745","doi":"10.2174/0115734110321087240918112556","title":"Novel Chiral HPLC Method for Accurate Identification and Quantification of R&S Enantiomers in Ropivacaine on Immobilized Chiral Stationary Phase: Development and Validation","year":2024,"lang":"en","type":"article","venue":"Current Analytical Chemistry","topic":"Analytical Chemistry and Chromatography","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada; Abbott Laboratories","keywords":"Enantiomer; Chiral stationary phase; Chromatography; Ropivacaine; Chiral derivatizing agent; Phase (matter); Chemistry; High-performance liquid chromatography; Chiral column chromatography; Identification (biology); Stationary phase; Pharmacology; Organic chemistry; Medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002928285,0.001612951,0.0009434044,0.001531306,0.0007075608,0.0009585224,0.001184158,0.00145845,0.001268067],"category_scores_gemma":[0.003555231,0.0005798507,0.000821923,0.0009161889,0.001105317,0.0008407775,0.0008706453,0.001557251,0.001260968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009085676,"about_ca_system_score_gemma":0.002789706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001727824,"about_ca_topic_score_gemma":0.002208677,"domain_scores_codex":[0.9956507,0.0008393798,0.0003314416,0.0008618914,0.002119728,0.0001969931],"domain_scores_gemma":[0.9982268,0.0003429557,0.0003333816,0.0001606977,0.0008193639,0.0001166562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000130362,0.0002086439,0.0006139233,0.0004898817,0.00005776201,0.000238918,0.00009783777,0.0008742431,0.9655447,0.0007505547,0.0003182087,0.03067491],"study_design_scores_gemma":[0.00004042985,0.0006039213,0.001193909,0.00008094901,0.00006228675,0.000948467,0.00004726846,0.009946535,0.9803309,0.0001689864,0.006499339,0.00007700863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2603889,0.01527699,0.7099217,0.0006507171,0.000518078,0.002174365,0.001559549,0.002552378,0.006957381],"genre_scores_gemma":[0.3817646,0.0104526,0.5984682,0.0006883679,0.0001874821,0.001873912,0.001416809,0.0002772217,0.004870841],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002928285,"threshold_uncertainty_score":0.01548642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0634991636253969,"score_gpt":0.3884959967233406,"score_spread":0.3249968330979437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}