{"id":"W4403223396","doi":"10.1007/s40257-024-00885-w","title":"Pembrolizumab for the First-Line Treatment of Recurrent Locally Advanced or Metastatic Merkel Cell Carcinoma: Results from the Single-Arm, Open-Label, Phase III KEYNOTE-913 Study","year":2024,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Medicine; Pembrolizumab; Merkel cell carcinoma; Oncology; Dermatology; Internal medicine; Carcinoma; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00433054,0.0008097566,0.001362146,0.0002069019,0.0003020779,0.0008052791,0.0006023168,0.0008989058,0.00189352],"category_scores_gemma":[0.001309916,0.0002532809,0.001465487,0.0002741994,0.0003993054,0.0006223171,0.0002601527,0.001779117,0.0005509324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006995305,"about_ca_system_score_gemma":0.0009108311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006000137,"about_ca_topic_score_gemma":0.00176665,"domain_scores_codex":[0.999338,0.0003486342,0.0000601847,0.00007179313,0.0001009184,0.00008049026],"domain_scores_gemma":[0.9986925,0.0002766935,0.0003933211,0.0001076193,0.0001473401,0.0003824642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5430976,0.03939883,0.03352185,0.004101854,0.00768838,0.0006118734,0.0006259598,0.003685061,0.09626843,0.0002770995,0.01045757,0.2602655],"study_design_scores_gemma":[0.3653404,0.445371,0.1568757,0.0003369885,0.005667237,0.001878745,0.0001888048,0.002265289,0.01131323,0.0002616184,0.01040143,0.0000996615],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820926,0.01241498,0.0007744975,0.0004692845,0.00006477655,0.00112692,0.0014055,0.0000857542,0.001565677],"genre_scores_gemma":[0.9897448,0.004241121,0.0008960369,0.0008213684,0.00008962411,0.0005736925,0.002719595,0.00002335923,0.0008902895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00433054,"threshold_uncertainty_score":0.02290237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.136869472562728,"score_gpt":0.4542531559561512,"score_spread":0.3173836833934232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}