{"id":"W4403223396","doi":"10.1007/s40257-024-00885-w","title":"Pembrolizumab for the First-Line Treatment of Recurrent Locally Advanced or Metastatic Merkel Cell Carcinoma: Results from the Single-Arm, Open-Label, Phase III KEYNOTE-913 Study","year":2024,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Medicine; Pembrolizumab; Merkel cell carcinoma; Oncology; Dermatology; Internal medicine; Carcinoma; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005961352,0.0003051851,0.001831812,0.00008851896,0.0001473513,0.00004119191,0.0005459627,0.00007309237,0.00004020266],"category_scores_gemma":[0.001132783,0.0001286186,0.0004706344,0.0003519841,0.0007728377,0.00009293668,0.00009891091,0.0004457596,0.000007609074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006424826,"about_ca_system_score_gemma":0.0009417385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002859721,"about_ca_topic_score_gemma":0.00009179332,"domain_scores_codex":[0.9955562,0.0005420229,0.002815975,0.0003929818,0.0003429864,0.0003498762],"domain_scores_gemma":[0.9873653,0.01006545,0.001407403,0.0005585051,0.0002889256,0.0003144293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1666043,0.04451689,0.0007905776,0.00007612717,0.003793554,0.003129551,0.001792519,0.00009269128,0.00008309835,0.00002682122,0.005153067,0.7739408],"study_design_scores_gemma":[0.4377,0.3663955,0.007829653,0.001203411,0.02692521,0.003338991,0.01063368,0.01461805,0.001379504,0.0005499804,0.1286582,0.000767878],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627511,0.01747083,0.000942511,0.01561884,0.001102435,0.001688148,0.0003191321,0.00001676402,0.00009027052],"genre_scores_gemma":[0.9949117,0.00295208,0.0008262426,0.0008557976,0.0002396115,0.00005240472,0.00002495519,0.00003802316,0.00009916042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.773173,"threshold_uncertainty_score":0.5244915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.136869472562728,"score_gpt":0.4542531559561512,"score_spread":0.3173836833934232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}