{"id":"W4403225357","doi":"10.1016/j.devcel.2024.09.011","title":"Sex-biased human thymic architecture guides T cell development through spatially defined niches","year":2024,"lang":"en","type":"article","venue":"Developmental Cell","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; BC Children's Hospital; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Wellcome Leap; British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Institute on Aging; Genome British Columbia; BC Children's Hospital; Michael Smith Health Research BC; Universities Space Research Association; Wellcome Trust; Canadian Institutes of Health Research; Li Ka Shing Foundation","keywords":"Biology; Niche; Ecological niche; Evolutionary biology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002880142,0.0006362679,0.0005456715,0.0002433731,0.0006483618,0.00009716456,0.0006353703,0.0005319513,0.002471881],"category_scores_gemma":[0.00001472548,0.0005552427,0.0001812082,0.0003051558,0.0003203076,0.0001372052,0.0004031337,0.0007725776,0.006420455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002609299,"about_ca_system_score_gemma":0.0006187979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001909673,"about_ca_topic_score_gemma":0.00016782,"domain_scores_codex":[0.9970005,0.0001938408,0.0008144956,0.0009277955,0.0001151408,0.0009482327],"domain_scores_gemma":[0.9992321,0.0001972754,0.0001316909,0.0003389063,0.00004743242,0.00005263184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005751368,0.0002851636,0.0005971373,0.000185987,0.000217679,0.00009703636,0.005229305,0.000007431011,0.9745745,0.0001720701,0.0131752,0.005400997],"study_design_scores_gemma":[0.0008969999,0.0001008723,0.0002140248,0.00006222195,0.00003453484,0.000110307,0.0003703775,6.793273e-7,0.6558924,0.0003043802,0.3415039,0.0005092661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.933165,0.009727331,0.0006464839,0.0002167029,0.00163978,0.0005064908,0.00003696296,0.0006013267,0.05345998],"genre_scores_gemma":[0.9357793,0.0001004221,0.007088786,0.000523151,0.00005872992,0.00008106623,0.0009493983,0.000088928,0.05533019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3283287,"threshold_uncertainty_score":0.9996899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701115730883428,"score_gpt":0.2274560341444428,"score_spread":0.2104448768356085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}