{"id":"W4403226180","doi":"10.1016/j.cjca.2024.08.162","title":"STIMULATING THE RETINOIC ACID BETA2 RECEPTOR ATTENUATES DOXORUBICIN-INDUCED ACUTE HEART FAILURE BY REDUCING THE PRO-FIBROTIC RESPONSE.","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Doxorubicin; Retinoic acid; Heart failure; Pharmacology; Internal medicine; Cardiology; Chemotherapy; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001609066,0.0003011103,0.0003349083,0.0002490798,0.0001426023,0.0002287401,0.0001793293,0.0003129567,0.003339285],"category_scores_gemma":[0.000229847,0.0001336928,0.0001814813,0.0001087543,0.0002839632,0.0002151838,0.00018417,0.0007269526,0.0005988348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681718,"about_ca_system_score_gemma":0.000372876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089554,"about_ca_topic_score_gemma":0.002366053,"domain_scores_codex":[0.9999107,0.00002796727,0.000006593792,0.000008890984,0.00001424086,0.00003169046],"domain_scores_gemma":[0.9998878,0.00001520738,0.00002981433,0.00001258654,0.00001084518,0.00004373971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0051434,0.0003757002,0.0004720552,0.0001032951,0.00002945065,0.0000681851,0.00003036695,0.0001415608,0.9796975,0.0001945928,0.0004789321,0.01326499],"study_design_scores_gemma":[0.001907114,0.01920628,0.02184781,0.00008398794,0.0002065617,0.0003927771,0.0003038648,0.00211754,0.9421557,0.0003929948,0.01135322,0.0000323321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811909,0.01024352,0.002408331,0.0008618723,0.0002316215,0.00008616882,0.0003400407,0.0002503862,0.004387205],"genre_scores_gemma":[0.9892083,0.003920882,0.001281657,0.0001550814,0.00007282731,0.00005914085,0.0002409981,0.00002990914,0.005031131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003339285,"threshold_uncertainty_score":0.01117104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009294970111808102,"score_gpt":0.2412525423183515,"score_spread":0.2319575722065434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}