{"id":"W4403229738","doi":"10.1111/ppl.14569","title":"Identification of clerodane diterpene modifying cytochrome <scp>P450</scp> (<scp>CYP728D26</scp>) in <i>Salvia divinorum</i> ‐ en route to psychotropic salvinorin A biosynthesis","year":2024,"lang":"en","type":"article","venue":"Physiologia Plantarum","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; National Research Foundation of Korea; Rural Development Administration; Ministry of Trade, Industry and Energy; Canterbury Medical Research Foundation; National Research Foundation","keywords":"Chemistry; Stereochemistry; Opioid receptor; Diterpene; Opioid; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008069478,0.0002804628,0.0001592052,0.0001781366,0.0001143052,0.0001722495,0.0001051904,0.0001849311,0.0006923899],"category_scores_gemma":[0.0001259282,0.00007156218,0.0002454621,0.0001779087,0.0001118165,0.00009768848,0.0000902779,0.0002154636,0.0004185534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002443003,"about_ca_system_score_gemma":0.000171049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008075436,"about_ca_topic_score_gemma":0.0008440571,"domain_scores_codex":[0.9999527,0.000006685198,0.000003861656,0.0000147136,0.00001260044,0.000009458781],"domain_scores_gemma":[0.9999223,0.000008844818,0.00002486284,0.0000112463,0.00001566403,0.00001705519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007019412,0.00002051504,0.0008142382,0.00002489817,0.00000670005,0.0001225904,0.00001002168,0.0001010478,0.9970208,0.00008408639,0.00007613479,0.001648751],"study_design_scores_gemma":[0.00001039992,0.0001215125,0.007079609,0.000003450274,0.00001509463,0.0004076089,0.00002208339,0.001060903,0.9875019,0.00006401849,0.003708005,0.000005509365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876867,0.001079252,0.00781026,0.0002046347,0.00002474192,0.00006043039,0.0015666,0.0001312043,0.00143618],"genre_scores_gemma":[0.9880292,0.0006096973,0.004797663,0.00004499055,0.00001109825,0.00001963217,0.003472111,0.00002067639,0.002994984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008075436,"threshold_uncertainty_score":0.002316296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008786017622785275,"score_gpt":0.2401333328649115,"score_spread":0.2313473152421262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}