{"id":"W4403233985","doi":"10.1002/smll.202405927","title":"Microneedles with Implantable Tip‐Accumulated Therapeutics for the Long‐Term Management of Psoriasis","year":2024,"lang":"en","type":"article","venue":"Small","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi; Université Laval; Université de Montréal","funders":"Faculté de pharmacie, Université de Montréal; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Association canadienne du médicament générique; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Psoriasis; Methotrexate; Transdermal; Phloretin; Pharmacology; Bioavailability; Drug; Drug delivery; In vivo; Medicine; Materials science; Nanotechnology; Chemistry; Surgery; Dermatology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279402,0.0002382674,0.0002377765,0.0002457565,0.00009436493,0.000227654,0.0002221673,0.0004212905,0.0007842496],"category_scores_gemma":[0.00009737942,0.0001064395,0.0002118082,0.0001456508,0.0001726988,0.000338811,0.0003016838,0.000500973,0.0003641453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002426943,"about_ca_system_score_gemma":0.0001379132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003161046,"about_ca_topic_score_gemma":0.0006293221,"domain_scores_codex":[0.9999026,0.00001371004,0.000005035749,0.00002207039,0.00004237998,0.00001410793],"domain_scores_gemma":[0.9999512,0.000009598234,0.00001881843,0.000004650725,0.000007805989,0.000007891768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003812183,0.00003085254,0.0000694769,0.0001860923,0.000007946449,0.00009691944,0.00001456992,0.0001086984,0.9733675,0.0002487738,0.0002080985,0.02562296],"study_design_scores_gemma":[0.0000348103,0.001123622,0.002151957,0.00004777737,0.00005779299,0.001039426,0.00003060337,0.002847841,0.9683898,0.0002582212,0.02399939,0.00001866891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.63699,0.2050954,0.1382121,0.001174818,0.0005378892,0.0004694831,0.0003503347,0.001396473,0.01577347],"genre_scores_gemma":[0.9190918,0.04116801,0.03147322,0.0004233417,0.0001078759,0.0001032367,0.0001317382,0.00005021033,0.007450584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007842496,"threshold_uncertainty_score":0.002623558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1527067931207087,"score_gpt":0.4342487762282172,"score_spread":0.2815419831075084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}