{"id":"W4403233985","doi":"10.1002/smll.202405927","title":"Microneedles with Implantable Tip‐Accumulated Therapeutics for the Long‐Term Management of Psoriasis","year":2024,"lang":"en","type":"article","venue":"Small","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi; Université Laval; Université de Montréal","funders":"Faculté de pharmacie, Université de Montréal; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Association canadienne du médicament générique; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Psoriasis; Methotrexate; Transdermal; Phloretin; Pharmacology; Bioavailability; Drug; Drug delivery; In vivo; Medicine; Materials science; Nanotechnology; Chemistry; Surgery; Dermatology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002903145,0.0001911334,0.0001750512,0.00005826724,0.0001535694,0.00002371334,0.0003149809,0.0001195681,0.0002235853],"category_scores_gemma":[0.000001135544,0.0001257972,0.00008562258,0.0001710259,0.0001635955,0.00006269596,0.00004994975,0.0002912105,0.00003319935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003930042,"about_ca_system_score_gemma":0.00003200183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000806369,"about_ca_topic_score_gemma":0.00002166386,"domain_scores_codex":[0.9989828,0.00006385196,0.0002468874,0.0002505994,0.0001006806,0.0003551256],"domain_scores_gemma":[0.9991878,0.0004394388,0.00005653742,0.0002132091,0.00005581956,0.00004714878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007761678,0.001325575,0.01402575,0.006540697,0.02286151,0.0004019953,0.005512833,0.02268673,0.05437878,0.01684662,0.006693089,0.8409647],"study_design_scores_gemma":[0.008817369,0.0009301999,0.01058636,0.0006848396,0.008669204,0.0001680625,0.001268864,0.02427331,0.2905167,0.001530606,0.6513225,0.001232026],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8289498,0.03454014,0.1164792,0.001671259,0.004876414,0.004184505,0.0008376318,0.0004142113,0.008046811],"genre_scores_gemma":[0.990369,0.003705162,0.001772891,0.0007748515,0.000128312,0.0001438776,0.00005165899,0.00004867385,0.003005628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8397327,"threshold_uncertainty_score":0.5129861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1527067931207087,"score_gpt":0.4342487762282172,"score_spread":0.2815419831075084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}