{"id":"W4403242017","doi":"10.1053/j.gastro.2024.09.033","title":"Early Life Exposure to Parental Crohn’s Disease Is Associated With Offspring’s Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn’s Disease","year":2024,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke; University of Toronto; Memorial University of Newfoundland; Centre Hospitalier Universitaire Sainte-Justine; University of Ottawa; Dalhousie University; Children's Hospital of Eastern Ontario; University of Manitoba; BC Children's Hospital; Sinai Health System; University of British Columbia; Queen's University; McMaster University; McGill University Health Centre; Hospital for Sick Children; Western University; Population Health Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Calgary; University of Alberta; Hôpital Maisonneuve-Rosemont; SickKids Foundation; Centre Hospitalier Universitaire de Sherbrooke; St. John’s Health Sciences Centre","funders":"University of Toronto; Canadian Association of Gastroenterology; Government of Ontario; Crohn's and Colitis Canada; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Offspring; Crohn's disease; Microbiome; Gut microbiome; Disease; Intestinal permeability; Medicine; Crohn disease; Intestinal Microbiome; Gastroenterology; Immunology; Biology; Internal medicine; Pregnancy; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002354152,0.0004081569,0.0003525172,0.000152557,0.0001102002,0.00006918568,0.000296669,0.0001664853,0.0000806062],"category_scores_gemma":[0.0002101368,0.0003706685,0.0002197921,0.000112507,0.0003397954,0.00001749531,0.0003423448,0.0002100523,0.00001550286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005264917,"about_ca_system_score_gemma":0.0002560315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005099954,"about_ca_topic_score_gemma":0.0002329127,"domain_scores_codex":[0.9975062,0.0003478969,0.0004308206,0.0009033685,0.0002178907,0.0005938123],"domain_scores_gemma":[0.9979976,0.00001879869,0.0001516228,0.0006654097,0.000162689,0.001003902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008500109,0.0002887328,0.9643199,0.0002013677,0.0005132116,0.001134905,0.0002185866,0.00003762501,0.02148133,0.00000969551,0.003173202,0.0001213263],"study_design_scores_gemma":[0.001548088,0.000575832,0.9963703,0.00008752123,0.0003651239,0.00001221938,0.00006758174,0.00006140873,0.000143715,0.00001701561,0.0005108133,0.0002403719],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950606,0.0005212923,0.00007633037,0.0005689813,0.0002433782,0.0005864498,0.002874805,0.00005650751,0.00001161413],"genre_scores_gemma":[0.9975444,0.00005408005,0.000097122,0.00134224,0.0002881471,0.0001035579,0.0003966978,0.00006581662,0.0001079282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0320504,"threshold_uncertainty_score":0.9998745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003681282050163574,"score_gpt":0.2042381513434602,"score_spread":0.2005568692932966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}