{"id":"W4403242017","doi":"10.1053/j.gastro.2024.09.033","title":"Early Life Exposure to Parental Crohn’s Disease Is Associated With Offspring’s Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn’s Disease","year":2024,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke; University of Toronto; Memorial University of Newfoundland; Centre Hospitalier Universitaire Sainte-Justine; University of Ottawa; Dalhousie University; Children's Hospital of Eastern Ontario; University of Manitoba; BC Children's Hospital; Sinai Health System; University of British Columbia; Queen's University; McMaster University; McGill University Health Centre; Hospital for Sick Children; Western University; Population Health Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Calgary; University of Alberta; Hôpital Maisonneuve-Rosemont; SickKids Foundation; Centre Hospitalier Universitaire de Sherbrooke; St. John’s Health Sciences Centre","funders":"University of Toronto; Canadian Association of Gastroenterology; Government of Ontario; Crohn's and Colitis Canada; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Offspring; Crohn's disease; Microbiome; Gut microbiome; Disease; Intestinal permeability; Medicine; Crohn disease; Intestinal Microbiome; Gastroenterology; Immunology; Biology; Internal medicine; Pregnancy; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002856481,0.0003587843,0.0003166787,0.0004305403,0.0004681314,0.0006684306,0.0002478725,0.0007427559,0.003600646],"category_scores_gemma":[0.002028222,0.0003367582,0.0004298661,0.0005102209,0.00026914,0.0003083722,0.0004402823,0.001095085,0.0002294581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000208419,"about_ca_system_score_gemma":0.0002212461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003425968,"about_ca_topic_score_gemma":0.003483201,"domain_scores_codex":[0.9997053,0.0001101797,0.00001635407,0.00006146371,0.00004001141,0.00006670932],"domain_scores_gemma":[0.9979606,0.0003160907,0.0008264077,0.0001559417,0.0001073534,0.0006336333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003325345,0.00008909491,0.9950145,0.0000148869,0.000127506,0.0004184359,0.0001442484,0.00004187119,0.001705285,0.00006997209,0.00009498695,0.001946675],"study_design_scores_gemma":[0.000002951613,0.00008307221,0.9990062,0.000008955454,0.00003034073,0.0004473562,0.0001079159,0.00006379069,0.00008730271,0.00004433866,0.0001135763,0.000004104393],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984961,0.000587733,0.0001044542,0.0001194732,0.00001769091,0.000001316594,0.000119356,0.000004077188,0.0005497576],"genre_scores_gemma":[0.9988808,0.0003105226,0.0001807315,0.00003092889,0.00001711741,0.000002456692,0.0001019789,0.000003545567,0.0004718569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003600646,"threshold_uncertainty_score":0.01204538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003681282050163574,"score_gpt":0.2042381513434602,"score_spread":0.2005568692932966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}