{"id":"W4403242165","doi":"10.1186/s12985-024-02514-8","title":"Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strain","year":2024,"lang":"en","type":"article","venue":"Virology Journal","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Institutes of Health; Cancer Research UK; NIHR Great Ormond Street Hospital Biomedical Research Centre; John Black Charitable Foundation; National Institute of Allergy and Infectious Diseases; University College London Hospitals NHS Foundation Trust; National Institute for Health and Care Research; Research to Prevent Blindness","keywords":"Attenuated vaccine; Virology; Downregulation and upregulation; Biology; Varicella zoster virus; Viral replication; Virus; Strain (injury); Immunology; Virulence; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009546242,0.0002002661,0.0002134449,0.0001789698,0.0001487288,0.0004058909,0.0001299873,0.000181635,0.0009354099],"category_scores_gemma":[0.0001278567,0.0001549881,0.0002944803,0.0001036204,0.0001864089,0.0002017928,0.0002669631,0.0002509512,0.0004247004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002826106,"about_ca_system_score_gemma":0.000221263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006032274,"about_ca_topic_score_gemma":0.0007575109,"domain_scores_codex":[0.9998216,0.00002073952,0.00002939568,0.00004251564,0.00004135745,0.00004437121],"domain_scores_gemma":[0.9998666,0.00001594388,0.00004292865,0.00002363875,0.00001530589,0.00003561545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005188657,0.00001001243,0.0004091934,0.00001916825,0.000002835493,0.00003377268,0.000008292514,0.00001504754,0.9991296,0.00002681831,0.000006269501,0.0002870923],"study_design_scores_gemma":[0.000008161197,0.0002044419,0.04785063,0.00001032745,0.00002126402,0.0005242244,0.00009022235,0.0004353257,0.9487316,0.00004624568,0.002072731,0.000004857423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977518,0.0007008165,0.0007250778,0.00001747779,0.00001330263,0.0000105053,0.0002056721,0.00003646105,0.0005389251],"genre_scores_gemma":[0.9977975,0.000260899,0.0005015783,0.00001181188,0.000002697269,0.000009468526,0.0003622707,0.00001057731,0.001043341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009354099,"threshold_uncertainty_score":0.003129244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02892775969299114,"score_gpt":0.3256941133036726,"score_spread":0.2967663536106814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}